Wandrup J, Kancir C
Clin Chem. 1986 Apr;32(4):706-8.
Patients with cancer are especially vulnerable to the development of hyper- and hypocalcemia. These disorders may be the basic clinical manifestation of cancer or may result from vigorous cancer treatment. During cytotoxic treatment of a child with leukemia we describe the longitudinal course of ionized calcium in a complex syndrome of hypocalcemia and hypoparathyroidism. The results suggest that the development of severe hypocalcemia can be explained on the basis of hypoparathyroidism in relation to hyperphosphatemia, hypomagnesemia, and acute renal failure. The low ionized calcium was unsuccessfully treated with several doses of calcium levulinate but successfully treated with 1 alpha-hydroxycholecalciferol.
癌症患者特别容易发生高钙血症和低钙血症。这些病症可能是癌症的基本临床表现，也可能是积极的癌症治疗所致。在对一名白血病患儿进行细胞毒性治疗期间，我们描述了低钙血症和甲状旁腺功能减退复杂综合征中离子钙的纵向变化过程。结果表明，严重低钙血症的发生可基于与高磷血症、低镁血症和急性肾衰竭相关的甲状旁腺功能减退来解释。数剂乙酰丙酸钙未能成功治疗低离子钙血症，但1α-羟基胆钙化醇成功治愈了该病症。
