Vawter G F, McGraw C A, Hug G, Kozakewich H P, McNaulty J, Mandell F
Forensic Sci Int. 1986 Feb-Mar;30(2-3):93-8. doi: 10.1016/0379-0738(86)90003-4.
Levels of 18 enzymes and metabolites were measured in liver obtained at autopsy from 41 infants, 28 of whom were found unexpectedly dead at home. Four infants had meningitis, 11 had pathologic findings not clearly sufficient to explain death (SUD), and 13 were considered totally unexplained pathologically (SIDS). The possible contributions of postmortem interval, age and diet to the results are reviewed. No characteristic metabolic profile was recognized amongst SUD and SIDS groups. It is speculated that the amount of glycogen found in liver may provide insight into premortal events and reflect the rapidity of the death mechanism. Five individuals (20%) were suspected of having major metabolic abnormality including glycogenosis (1), urea cycle defect (1), and possibly abnormal levels of carnitine palmityl transferase (3).
对41名婴儿尸检时获取的肝脏进行了18种酶和代谢物水平的检测，其中28名婴儿是在家中意外死亡。4名婴儿患有脑膜炎，11名婴儿有病理发现，但不足以明确解释死因（不明原因死亡），13名婴儿在病理上被认为完全无法解释（婴儿猝死综合征）。本文回顾了死后间隔时间、年龄和饮食对检测结果可能产生的影响。在不明原因死亡和婴儿猝死综合征组中未发现特征性的代谢谱。据推测，肝脏中糖原的含量可能有助于了解死前事件，并反映死亡机制的快速性。5名个体（20%）被怀疑存在主要代谢异常，包括糖原贮积症（1例）、尿素循环缺陷（1例），以及可能存在肉碱棕榈酰转移酶水平异常（3例）。
