Colorectal Surgical Unit, The Royal Melbourne Hospital, Parkville, Victoria, Australia.
Department of General Surgical Specialties, The Royal Melbourne Hospital, Parkville, Victoria, Australia.
ANZ J Surg. 2022 Jan;92(1-2):27-33. doi: 10.1111/ans.17221. Epub 2021 Sep 27.
There are multiple data sources relating to colorectal cancer (CRC) nationwide. Prospective clinical cancer databases, population-based registries and linked administrative data are powerful tools in clinical outcomes research and provide real-world perspective on cancer treatments. This study aims to review the different Australian data sources for CRC from the perspective of conducting comparative research studies using a PICO (patient, intervention, comparison, outcome) framework.
Data dictionaries from the different data sources were evaluated for the types of exposure and outcome variables contained to highlight their differing research utility.
State or territory-based cancer registries contain limited histology, cancer staging and treatment detail. They enable investigation of population-level patterns in overall survival (OS) of cancer patients with different demographics. Prospective clinical cancer databases contain more detail, especially surgical. Their strength is in auditing short-term surgical outcomes. They vary in the amount of data collected for other cancer treatments and completion of follow up data. Linked administrative databases have broad population coverage but less surgical detail. They provide population-level data on treatment patterns, short-term outcome measures and OS, as well as long-term surgical outcomes such as identifying patients who did not undergo stoma reversal. These databases cannot assess disease-free survival.
Of the various CRC data sources within Australia, linked administrative databases have the potential to provide the widest population coverage combined with the broadest range of exposures and outcomes, and arguably the most research utility.
有多个与结直肠癌（CRC）相关的全国性数据来源。前瞻性临床癌症数据库、基于人群的登记处和链接的行政数据是临床结果研究中的有力工具，为癌症治疗提供了真实世界的视角。本研究旨在从使用 PICO（患者、干预、比较、结果）框架进行比较研究的角度，回顾澳大利亚不同的 CRC 数据来源。
评估不同数据源的数据字典，以突出其不同的研究用途，包含的暴露和结局变量类型。
州或地区癌症登记处包含有限的组织学、癌症分期和治疗细节。它们能够调查不同人口统计学特征的癌症患者总体生存率（OS）的人群水平模式。前瞻性临床癌症数据库包含更多细节，特别是手术方面。它们的优势在于审核短期手术结果。它们在其他癌症治疗和完成随访数据方面收集的数据量有所不同。链接的行政数据库具有广泛的人群覆盖范围，但手术细节较少。它们提供有关治疗模式、短期结局指标和 OS 的人群水平数据，以及长期手术结果，如确定未进行造口反转的患者。这些数据库无法评估无病生存率。
在澳大利亚的各种 CRC 数据来源中，链接的行政数据库有可能提供最广泛的人群覆盖范围，结合最广泛的暴露和结局，并且可以说是最具研究用途。
