Whittemore P B
J Clin Psychol. 1986 Mar;42(2):260-3. doi: 10.1002/1097-4679(198603)42:2<260::aid-jclp2270420206>3.0.co;2-t.
The phenylthiocarbamide (PTC) taste test was investigated for its potential as a genetically based biological marker for depression. One hundred and one male and female adults (including 6 patients hospitalized for depression), aged 18-36, completed a multifactor depression questionnaire that included the Beck Depression Inventory (BDI), a scale that measures severity of depression in mother and father, and a commercially prepared PTC (paper) taste test. As predicted, PTC tasters reported significantly higher levels of depression on the BDI than nontasters (p less than .05); also, they scored higher on 5 of the 21 items (p less than .05). Significantly more subjects who reported a mother debilitated by depression were PTC tasters (p less than .05). Limitations and implications of these findings are discussed.
对苯硫脲（PTC）味觉测试作为抑郁症基于基因的生物学标志物的潜力进行了研究。101名年龄在18至36岁之间的成年男女（包括6名因抑郁症住院的患者）完成了一份多因素抑郁症问卷，其中包括贝克抑郁量表（BDI）、一个测量父母抑郁严重程度的量表以及一份市售的PTC（纸片）味觉测试。正如预期的那样，PTC尝味者在BDI上报告的抑郁水平显著高于非尝味者（p小于0.05）；此外，他们在21个项目中的5个项目上得分更高（p小于0.05）。报告称母亲因抑郁症而衰弱的受试者中，PTC尝味者明显更多（p小于0.05）。讨论了这些发现的局限性和意义。
