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在生理条件下交联的透明质酸水凝胶：合成与生物医学应用

Hyaluronic Acid Hydrogels Crosslinked in Physiological Conditions: Synthesis and Biomedical Applications.

作者信息

Pérez Luis Andrés, Hernández Rebeca, Alonso José María, Pérez-González Raúl, Sáez-Martínez Virginia

机构信息

Instituto de Ciencia y Tecnología de Polímeros (ICTP-CSIC), c/Juan de la Cierva, 3, 28006 Madrid, Spain.

i+Med S. Coop. Parque Tecnológico de Álava, Albert Einstein 15, Nave 15, 01510 Vitoria-Gasteiz, Spain.

出版信息

Biomedicines. 2021 Aug 30;9(9):1113. doi: 10.3390/biomedicines9091113.

DOI:10.3390/biomedicines9091113
PMID:34572298
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8466770/
Abstract

Hyaluronic acid (HA) hydrogels display a wide variety of biomedical applications ranging from tissue engineering to drug vehiculization and controlled release. To date, most of the commercially available hyaluronic acid hydrogel formulations are produced under conditions that are not compatible with physiological ones. This review compiles the currently used approaches for the development of hyaluronic acid hydrogels under physiological/mild conditions. These methods include dynamic covalent processes such as boronic ester and Schiff-base formation and click chemistry mediated reactions such as thiol chemistry processes, azide-alkyne, or Diels Alder cycloaddition. Thermoreversible gelation of HA hydrogels at physiological temperature is also discussed. Finally, the most outstanding biomedical applications are indicated for each of the HA hydrogel generation approaches.

摘要

透明质酸（HA）水凝胶展现出广泛的生物医学应用，涵盖从组织工程到药物载体化及控释等领域。迄今为止，大多数市售的透明质酸水凝胶制剂是在与生理条件不兼容的条件下生产的。本综述汇编了目前在生理/温和条件下开发透明质酸水凝胶所使用的方法。这些方法包括动态共价过程，如硼酸酯和席夫碱的形成，以及点击化学介导的反应，如硫醇化学过程、叠氮化物-炔烃反应或狄尔斯-阿尔德环加成反应。还讨论了HA水凝胶在生理温度下的热可逆凝胶化。最后，指出了每种HA水凝胶生成方法最突出的生物医学应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/777f/8466770/2016537f52e1/biomedicines-09-01113-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/777f/8466770/fd9be1d505d1/biomedicines-09-01113-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/777f/8466770/79f97fb53785/biomedicines-09-01113-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/777f/8466770/496f7af18806/biomedicines-09-01113-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/777f/8466770/a24266b4721d/biomedicines-09-01113-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/777f/8466770/c8fc5712d698/biomedicines-09-01113-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/777f/8466770/013d8e10c002/biomedicines-09-01113-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/777f/8466770/b4c07836073f/biomedicines-09-01113-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/777f/8466770/840081d0f3de/biomedicines-09-01113-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/777f/8466770/21b2ac275ab9/biomedicines-09-01113-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/777f/8466770/2016537f52e1/biomedicines-09-01113-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/777f/8466770/fd9be1d505d1/biomedicines-09-01113-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/777f/8466770/79f97fb53785/biomedicines-09-01113-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/777f/8466770/496f7af18806/biomedicines-09-01113-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/777f/8466770/a24266b4721d/biomedicines-09-01113-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/777f/8466770/c8fc5712d698/biomedicines-09-01113-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/777f/8466770/013d8e10c002/biomedicines-09-01113-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/777f/8466770/b4c07836073f/biomedicines-09-01113-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/777f/8466770/840081d0f3de/biomedicines-09-01113-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/777f/8466770/21b2ac275ab9/biomedicines-09-01113-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/777f/8466770/2016537f52e1/biomedicines-09-01113-g010.jpg

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