Fujimura A, Ebihara A
Life Sci. 1986 Mar 31;38(13):1215-20. doi: 10.1016/0024-3205(86)90176-1.
The present experiment was undertaken to determine whether or not the effects of furosemide depend upon the administration time and, if so, to study the mechanism(s) for these variations. After administration of furosemide (5 mg/kg) in Wistar rats at 10:00 or at 22:00, urine volume and urinary excretion of sodium, furosemide, and prostaglandin E2 (PGE2) were measured. Urine volume and urinary excretion of sodium and furosemide, but not PGE2, were significantly greater when furosemide was administered at 10:00 than when it was administered at 22:00. There was a good correlation between the urinary output of furosemide and the urine volume, or the urinary sodium. It is concluded that the effects of furosemide vary with the administration time and these variations depend upon the amount of furosemide secreted in urine.
本实验旨在确定呋塞米的作用是否取决于给药时间，若如此，则研究这些变化的机制。在10:00或22:00给Wistar大鼠注射呋塞米（5mg/kg）后，测量尿量以及钠、呋塞米和前列腺素E2（PGE2）的尿排泄量。当呋塞米在10:00给药时，尿量以及钠和呋塞米的尿排泄量显著高于22:00给药时，但PGE2并非如此。呋塞米的尿排出量与尿量或尿钠之间存在良好的相关性。得出的结论是，呋塞米的作用随给药时间而变化，且这些变化取决于尿中分泌的呋塞米量。
