NF-κB 依赖性和非依赖性（兼职）IκBα 在分化和癌症中的作用
NF-κB-Dependent and -Independent (Moonlighting) IκBα Functions in Differentiation and Cancer.
作者信息
Espinosa Lluís, Marruecos Laura
机构信息
Cancer Research Program, Institut Mar d'Investigacions Mèdiques, CIBERONC, Hospital del Mar, Doctor Aiguader 88, 08003 Barcelona, Spain.
出版信息
Biomedicines. 2021 Sep 21;9(9):1278. doi: 10.3390/biomedicines9091278.
IκBα is considered to play an almost exclusive role as inhibitor of the NF-κB signaling pathway. However, previous results have demonstrated that SUMOylation imposes a distinct subcellular distribution, regulation, NF-κB-binding affinity and function to the IκBα protein. In this review we discuss the main alterations of IκBα found in cancer and whether they are (most likely) associated with NF-κB-dependent or NF-κB-independent (moonlighting) activities of the protein.
IκBα被认为几乎是NF-κB信号通路的唯一抑制剂。然而，先前的研究结果表明，SUMO化作用赋予IκBα蛋白独特的亚细胞分布、调节、NF-κB结合亲和力和功能。在这篇综述中，我们讨论了在癌症中发现的IκBα的主要变化，以及它们是否（很可能）与该蛋白的NF-κB依赖性或NF-κB非依赖性（兼职）活性相关。
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