Ren Dan-Yang, Yuan Xin-Rong, Tu Cai-Xia, Shen Jian-Ling, Li Yun-Wei, Yan Ai-Hua, Ru Yi, Han Hui-Yun, Yang Yan-Ming, Liu Yan, Li Hui-Ying
Pharmaceutical Preparation Section, Children's Hospital of Kunming Medical University, Kunming, China.
Department of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Front Pharmacol. 2021 Dec 20;12:726908. doi: 10.3389/fphar.2021.726908. eCollection 2021.
Long non-coding RNAs (lncRNAs) play important roles in human diseases. They control gene expression levels and influence various biological processes through multiple mechanisms. Functional abnormalities in lncRNAs are strongly associated with occurrence and development of various diseases. LINC00472, which is located on chromosome 6q13, is involved in several human diseases, particularly cancers of the breast, lung, liver, osteosarcoma, bladder, colorectal, ovarian, pancreatic and stomach. Importantly, LINC00472 can be used as a biomarker for breast cancer cell sensitivity to chemotherapeutic regimens, including doxorubicin. LINC00472 is regulated by microRNAs and several signaling pathways. However, the significance of LINC00472 in human diseases has not been clearly established. In this review, we elucidate on the significance of LINC00472 in various human diseases, indicating that LINC00472 may be a diagnostic, prognostic as well as therapeutic target for these diseases.
长链非编码RNA（lncRNAs）在人类疾病中发挥着重要作用。它们控制基因表达水平，并通过多种机制影响各种生物学过程。lncRNAs的功能异常与多种疾病的发生和发展密切相关。位于6号染色体q13上的LINC00472参与了多种人类疾病，特别是乳腺癌、肺癌、肝癌、骨肉瘤、膀胱癌、结直肠癌、卵巢癌、胰腺癌和胃癌。重要的是，LINC00472可作为乳腺癌细胞对包括阿霉素在内的化疗方案敏感性的生物标志物。LINC00472受微小RNA和多种信号通路调控。然而，LINC00472在人类疾病中的意义尚未明确确立。在本综述中，我们阐明了LINC00472在各种人类疾病中的意义，表明LINC00472可能是这些疾病的诊断、预后及治疗靶点。
