Terwinghe G, Daumerie J, Nicaise C, Rosillon O
Acta Neurol Belg. 1978 Jan-Feb;78(1):30-6.
Since the advent of intensive care units the number of cases of posthypoxic action or intention myoclonus has greatly increased. This has given rise to renewed research into the physiopathology and therapy of the disease. The latent effective treatment is based on derivatives of benzodiazepine, and especially L-5-hydroxytryptophan, administered with or without an inhibitor of peripheral decarboxylase. The disadvantages of these compounds, associated with their secondary effects, make our fortuitous discovery of the effectively curative action of piracetam doubly valuable.
自从重症监护病房出现以来，缺氧后动作性或意向性肌阵挛的病例数量大幅增加。这引发了对该疾病生理病理学和治疗方法的重新研究。潜在的有效治疗方法基于苯二氮䓬衍生物，尤其是L-5-羟色氨酸，可联合或不联合外周脱羧酶抑制剂使用。这些化合物的缺点及其副作用，使得我们偶然发现的吡拉西坦的有效治疗作用显得倍加珍贵。
