Michelotti Tainara Cristina, Trevisi Erminio, Osorio Johan S
Dairy and Food Science Department, South Dakota State University, Brookings, SD 57007, USA.
Department of Animal Sciences, Food and Nutrition (DIANA), Facoltà di Scienze Agrarie, Alimentari e Ambientali, Università Cattolica del Sacro Cuore, 29122 Piacenza, Italy.
Antioxidants (Basel). 2021 Sep 16;10(9):1478. doi: 10.3390/antiox10091478.
The objective of the present study was to evaluate the effects of an antioxidant and anti-inflammatory compound found in rosemary plants () named carnosic acid during the transition period of dairy cows. From day 1 to 3 after calving, 16 multiparous Holstein cows received a daily intravenous infusion of either 500 mL of saline (NaCl 0.9%; Saline; = 8) or carnosic acid at a rate of 0.3 mg/kg of BW supplied in 500 mL of saline (CA; = 8). Blood samples were taken at -7, 2, 5, 7, 14, and 21 d relative to parturition, then analyzed for metabolites related to energy metabolism, muscle mass catabolism, liver function, inflammation, and oxidative stress. CA infusion tended to improve milk performance; however, DMI was unaffected by treatment. At 2 d relative to parturition, CA cows had lower blood concentrations of haptoglobin, paraoxonase, FRAP, and NO than saline cows. After treatment infusions, haptoglobin remained lower in CA cows than saline at 5 d relative to parturition. Our results demonstrate that carnosic acid promoted positive responses on inflammation and oxidative stress biomarkers and may promote beneficial effects on lactation performance in peripartal dairy cows.
本研究的目的是评估迷迭香叶中发现的一种名为肌醇六磷酸的抗氧化和抗炎化合物在奶牛围产期的作用。在产犊后的第1至3天，16头经产荷斯坦奶牛每天静脉输注500毫升生理盐水（0.9%氯化钠；生理盐水；n = 8）或500毫升生理盐水中以0.3毫克/千克体重的速率供应的肌醇六磷酸（CA；n = 8）。在分娩前7天、产后2天、5天、7天、14天和21天采集血样，然后分析与能量代谢、肌肉质量分解代谢、肝功能、炎症和氧化应激相关的代谢物。输注CA有改善产奶性能的趋势；然而，干物质采食量不受处理影响。在分娩后第2天，CA组奶牛的触珠蛋白、对氧磷酶、铁还原抗氧化能力（FRAP）和一氧化氮（NO）的血浓度低于生理盐水组奶牛。处理输注后，在分娩后第5天，CA组奶牛的触珠蛋白仍低于生理盐水组。我们的结果表明，肌醇六磷酸对炎症和氧化应激生物标志物产生了积极反应，并可能对围产期奶牛的泌乳性能产生有益影响。
