采用4DST PET/CT对结直肠癌和腺瘤进行细胞增殖PET成像

Cell Proliferation PET Imaging with 4DST PET/CT in Colorectal Adenocarcinoma and Adenoma.

作者信息

Minamimoto Ryogo, Endo Hisako

机构信息

Division of Nuclear Medicine, Department of Radiology, National Center for Global Health and Medicine, Tokyo 1628655, Japan.

Department of Clinical Pathology, Edogawa Hospital, Tokyo 1330052, Japan.

出版信息

Diagnostics (Basel). 2021 Sep 10;11(9):1658. doi: 10.3390/diagnostics11091658.

DOI:10.3390/diagnostics11091658

PMID:34573999

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8466967/

Abstract

An age of 70-year-old man was incidentally found two focal high 2-[18F]-fluoro-2-deoxy-d-glucose (FDG) uptake in the descending colon and in the sigmoid colon. We observed the feature of these two areas in the preplanned 4'-[methyl-11C]-thiothymidine (4DST) positron emission tomography (PET)/computed Tomography (CT)providing cell proliferation imaging. A mass forming high 4DST uptake in the descending colon and focal moderate 4DST uptake in the sigmoid colon was confirmed, and that were proven pathologically as adenocarcinoma and moderate to severe type tubular adenoma, respectively. This is the first report to present that colorectal adenoma can be visualized by proliferation PET imaging and the degree of uptake may enable discrimination of colorectal adenoma from adenocarcinoma, based on pathological considerations.

摘要

一名70岁男性在偶然情况下被发现降结肠和乙状结肠有两处局灶性高2-[18F]-氟-2-脱氧-D-葡萄糖（FDG）摄取。我们在预先计划的4'-[甲基-11C]-硫代胸腺嘧啶核苷（4DST）正电子发射断层扫描（PET）/计算机断层扫描（CT）中观察了这两个区域的特征，该检查可提供细胞增殖成像。确认降结肠有一个形成高4DST摄取的肿块，乙状结肠有局灶性中度4DST摄取，病理检查分别证实为腺癌和中重度管状腺瘤。这是首次报告显示结直肠腺瘤可通过增殖PET成像可视化，并且基于病理考虑，摄取程度可能有助于区分结直肠腺瘤和腺癌。