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唾液腺肿瘤的增殖性PET/CT成像

Proliferation PET/CT Imaging of Salivary Gland Tumor.

作者信息

Minamimoto Ryogo

机构信息

National Center for Global Health and Medicine, Department of Radiology, Division of Nuclear Medicine, Tokyo 162-8655, Japan.

出版信息

Diagnostics (Basel). 2021 Nov 8;11(11):2065. doi: 10.3390/diagnostics11112065.

DOI:10.3390/diagnostics11112065
PMID:34829412
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8619383/
Abstract

Salivary gland tumors are rare neoplasms which vary in terms of origin and malignant potential. 2-[18F]-fluoro-2-deoxy-d-glucose (FDG)-positron emission tomography (PET) has limited ability to differentiate between different types of salivary gland tumors because both Warthin's tumors and pleomorphic adenomas usually show increased FDG uptake, with no statistically significant difference in standardized uptake value (SUV) compared with malignant salivary gland tumors. Here, we discuss 4'-[methyl-11C]-thiothymidine (4DST) PET, which provides cell proliferation imaging capable of demonstrating intense uptake in parotid carcinoma and Warthin's tumor, but no uptake in parotid pleomorphic adenoma. This is the first report of the potential of proliferation PET/ computed tomography (CT) imaging for characterizing salivary gland tumors based on the molecular pathogenesis of the tumor.

摘要

涎腺肿瘤是一种罕见的肿瘤，其起源和恶性潜能各不相同。2-[18F]-氟-2-脱氧-D-葡萄糖（FDG）-正电子发射断层扫描（PET）区分不同类型涎腺肿瘤的能力有限，因为沃辛瘤和多形性腺瘤通常都显示出FDG摄取增加，与恶性涎腺肿瘤相比，标准化摄取值（SUV）无统计学显著差异。在此，我们讨论4'-[甲基-11C]-硫代胸腺嘧啶核苷（4DST）PET，它提供细胞增殖成像，能够显示在腮腺癌和沃辛瘤中有强烈摄取，但在腮腺多形性腺瘤中无摄取。这是第一篇基于肿瘤分子发病机制，探讨增殖PET/计算机断层扫描（CT）成像在涎腺肿瘤特征化方面潜力的报告。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/44ce/8619383/98a452756016/diagnostics-11-02065-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/44ce/8619383/c1af77a5587b/diagnostics-11-02065-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/44ce/8619383/7ccf7a573e36/diagnostics-11-02065-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/44ce/8619383/98a452756016/diagnostics-11-02065-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/44ce/8619383/c1af77a5587b/diagnostics-11-02065-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/44ce/8619383/7ccf7a573e36/diagnostics-11-02065-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/44ce/8619383/98a452756016/diagnostics-11-02065-g003.jpg

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本文引用的文献

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Comparison of 11C-4DST and 18F-FDG PET/CT imaging for advanced renal cell carcinoma: preliminary study.11C-4DST 和 18F-FDG PET/CT 成像在晚期肾细胞癌中的比较：初步研究。
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