Raptis Dimitrios G, Sinani Olga, Rapti Georgia G, Papanikolaou Aikaterini, Dadouli Katerina, Ntellas Panagiotis, Kapsalaki Eftychia Z, Malli Foteini, Gourgoulianis Konstantinos I, Xiromerisiou Georgia
Respiratory Medicine Department, School of Medicine, University of Thessaly, 41110 Larissa, Greece.
Faculty of Medicine, School of Health Sciences, University of Thessaly, 41222 Larissa, Greece.
Diagnostics (Basel). 2021 Sep 13;11(9):1673. doi: 10.3390/diagnostics11091673.
Obstructive sleep apnea hypopnea syndrome (OSAHS) is associated with increased risk of cerebrovascular disease. The aim of the present study was to investigate the association between the presence of the small vessel disease (SVD) of the brain in patients with OSAHS. The study included 24 patients with moderate to severe OSAHS and 34 healthy volunteers. All the subjects underwent magnetic resonance imaging (MRI) of the brain, in order to sought periventricular white matter (PVWM), deep white matter (DWM) and brainstem SVD. Among patients with OSAHS, 79.1% had SVD (grade 1-3, Fazekas score) in DWM and 91.7% in PVWM while 22.4% had brainstem-white matter hyperintensities (B-WMH). Patients with OSAHS had a much higher degree of SVD in the DWM and PVWM compared to the control group ( < 0.001). The multivariate analysis showed an independent significant association of OSAHS with SVD (DWM and PVWM) ( = 0.033, OR 95% CI: 8.66 (1.19-63.08) and: = 0.002, OR 95% CI: 104.98 (5.15-2141)). The same analysis showed a moderate association of OSAHS with B-WMH ( = 0.050, OR 15.07 (0.97-234.65)). Our study demonstrated an independent significant association of OSAHS with SVD and a moderate association of OSAHS with B-WMH.
阻塞性睡眠呼吸暂停低通气综合征（OSAHS）与脑血管疾病风险增加相关。本研究的目的是调查OSAHS患者脑小血管疾病（SVD）的存在情况之间的关联。该研究纳入了24例中重度OSAHS患者和34名健康志愿者。所有受试者均接受脑部磁共振成像（MRI）检查，以寻找脑室周围白质（PVWM）、深部白质（DWM）和脑干SVD。在OSAHS患者中，79.1%的患者DWM存在SVD（1-3级，法泽卡斯评分），91.7%的患者PVWM存在SVD，而22.4%的患者有脑干白质高信号（B-WMH）。与对照组相比，OSAHS患者DWM和PVWM的SVD程度要高得多（<0.001）。多变量分析显示OSAHS与SVD（DWM和PVWM）存在独立显著关联（=0.033，OR 95%CI：8.66（1.19-63.08）；以及：=0.002，OR 95%CI：104.98（5.15-2141））。同样的分析显示OSAHS与B-WMH存在中度关联（=0.050，OR 15.07（0.97-234.65））。我们的研究表明OSAHS与SVD存在独立显著关联，与B-WMH存在中度关联。
