Lee Tae Young, Jeon Young-Jee, Kim Chung Reen, Kang Byung Ju, Park Gyung-Min
Department of Radiology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan 44033, Korea.
Department of Family Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan 44033, Korea.
Healthcare (Basel). 2021 Sep 10;9(9):1197. doi: 10.3390/healthcare9091197.
Computed tomography (CT) is a reference method for measuring skeletal muscle mass, and the amount of fat in the skeletal muscle can be calculated based on CT attenuation. This study aimed to comprehensively investigate the effect of muscle quality and quantity on metabolic syndrome (MetS) according to sex. This retrospective cross-sectional study enrolled 8081 individuals aged ≥20 years who underwent self-referral abdominopelvic CT at our hospital. The total abdominal muscle area (TAMA), low-attenuation abdominal muscle area (LAMA), normal-attenuation abdominal muscle area (NAMA), and extramyocellular lipid area (EMCLA) were measured using cross-sectional CT data of the L3 lumbar vertebrae. The TAMA and NAMA showed negative correlations with risk factors for MetS and a positive correlation with high-density lipoprotein cholesterol, whereas the LAMA and EMCLA showed an inverse trend in both the sexes ( < 0.001). After adjusting for various factors, a higher LAMA index and the ratio of LAMA to TAMA were associated with a higher prevalence of MetS. High TAMA indices were associated with a lower prevalence of MetS. Furthermore, muscle quality and quantity were associated with the prevalence of MetS in both males and females. However, the LAMA showed a stronger association with MetS in males than in females.
计算机断层扫描（CT）是测量骨骼肌质量的参考方法，并且可以根据CT衰减来计算骨骼肌中的脂肪量。本研究旨在根据性别全面调查肌肉质量和数量对代谢综合征（MetS）的影响。这项回顾性横断面研究纳入了8081名年龄≥20岁且在我院接受了自转诊腹部盆腔CT检查的个体。使用L3腰椎的横断面CT数据测量总腹部肌肉面积（TAMA）、低衰减腹部肌肉面积（LAMA）、正常衰减腹部肌肉面积（NAMA）和细胞外脂质面积（EMCLA）。TAMA和NAMA与MetS的危险因素呈负相关，与高密度脂蛋白胆固醇呈正相关，而LAMA和EMCLA在两性中均呈相反趋势（<0.001）。在调整各种因素后，较高的LAMA指数以及LAMA与TAMA的比值与MetS的较高患病率相关。较高的TAMA指数与MetS的较低患病率相关。此外，肌肉质量和数量与男性和女性的MetS患病率均相关。然而，LAMA与男性MetS的关联比与女性更强。
