肾移植中乳酸、丙酮酸和α-酮戊二酸的排泄模式。
The excretional patterns of lactate, pyruvate and alpha-ketoglutarate in renal transplants.
作者信息
Hansen H E, Skov P E
出版信息
Acta Med Scand. 1978;203(3):187-9. doi: 10.1111/j.0954-6820.1978.tb14854.x.
The excretional patterns of lactate, pyruvate and alpha-ketoglutarate were investigated after renal transplantation in 36 patients. Fourteen patients had received a living-donor kidney with short ischemia time and good initial graft function, 22 had a cadaver transplant with an initial 125iothalamate clearance of more than 6 ml/min. The excretion of lactate and pyruvate did not vary significantly from that seen in normal controls or patients with uremia. In six patients with cadaver transplants, clearance values of alpha-ketoglutarate exceeded that of the glomerular filtration rate, indicating a net tubular secretion of this substance. During acute rejection episodes in 5 patients, no changes were seen in the excretional patterns of lactate, pyruvate and alpha-ketoglutarate.
对36例肾移植患者乳酸、丙酮酸和α-酮戊二酸的排泄模式进行了研究。14例患者接受了来自活体供者的肾脏，缺血时间短，移植肾初始功能良好；22例接受了尸体肾移植，初始碘他拉酸盐清除率超过6 ml/min。乳酸和丙酮酸的排泄与正常对照组或尿毒症患者相比无显著差异。在6例尸体肾移植患者中，α-酮戊二酸的清除值超过肾小球滤过率，表明该物质有肾小管净分泌。5例患者发生急性排斥反应时，乳酸、丙酮酸和α-酮戊二酸的排泄模式未见变化。
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