Department of Pharmaceutical Chemistry, School of Pharmacy, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
Int J Mol Sci. 2021 Sep 10;22(18):9788. doi: 10.3390/ijms22189788.
Cinnamic acid and its derivatives have been studied for a variety of biological properties, including anti-inflammatory, antioxidant, anticancer, antihypertensive, and antibacterial. Many hybrids of cinnamic derivatives with other bioactive molecules have been synthesized and evaluated as nitric oxide (NO) donors. Since NO plays a significant role in various biological processes, including vasodilation, inflammation, and neurotransmission, NO donor groups are incorporated into the structures of already-known bioactive molecules to enhance their biological properties. In this review, we present cinnamic hybrids with NO-donating ability useful in the treatment of several diseases.
肉桂酸及其衍生物具有多种生物学特性，包括抗炎、抗氧化、抗癌、降压和抗菌。许多肉桂酸衍生物与其他生物活性分子的杂化物已被合成，并作为一氧化氮（NO）供体进行了评估。由于 NO 在包括血管舒张、炎症和神经传递在内的各种生物学过程中发挥着重要作用，NO 供体基团被引入到已知生物活性分子的结构中，以增强它们的生物学特性。在这篇综述中，我们介绍了具有治疗多种疾病作用的含 NO 供体的肉桂酸杂化物。
