Budzinska K, Romaniuk J R
Bull Eur Physiopathol Respir. 1986 Jan-Feb;22(1):65-73.
Investigations were undertaken to study the characteristics of phrenic reflexes with partial or total elimination of the descending neuronal pathways. Experiments were performed on 17 decerebrate, vagotomized, paralysed and artificially ventilated rabbits. The experimental procedure included a midsagittal section of the medulla or a hemisection followed by a total transection of the spinal cord at C1. The effects of compression of the rostral or caudal parts of the thorax, pressure on the muscles at the lumbar level and passive movements of the hindlimb were studied on the efferent vagal and phrenic neurograms. Partial elimination of the descending pathways evoked an increase in the intensity of the spinal reflexes. Characteristics of the reflexes which we have obtained after lesions of the medulla or spinal cord enable us to search for their central path. After transection of the spinal cord, no sustained phasic phrenic nerve activities were observed. The results suggest that after high cordotomy the phrenic motoneuronal pool has a potential capability for generating phasic bursts and additional inputs are required for their development.
开展了相关研究，以探讨在部分或完全消除下行神经通路的情况下膈神经反射的特征。对17只去大脑、切断迷走神经、麻痹并进行人工通气的兔子进行了实验。实验步骤包括在延髓做矢状中切或半切，随后在C1水平完全横断脊髓。在传出迷走神经和膈神经电图上研究了胸部头端或尾端受压、腰部肌肉受压以及后肢被动运动的影响。下行通路的部分消除引起脊髓反射强度增加。在延髓或脊髓损伤后获得的反射特征使我们能够探寻其中枢路径。脊髓横断后，未观察到持续的膈神经相位活动。结果表明，高位脊髓切断术后，膈运动神经元池具有产生相位性爆发的潜在能力，但其发展需要额外的输入。
