Budzińska K, Głowicki K, Romaniuk J R
Acta Neurobiol Exp (Wars). 1984;44(6):249-62.
Long-lasting effects of vagal input on phrenic (Phr) and external intercostal (EI) motoneuronal output were studied on 16 anesthetized rabbits breathing spontaneously or paralysed and ventilated by a phrenic nerve-driven pump. Withholding of ventilation by tracheal occlusion or by switching off the servorespirator maintained for seven breaths evoked a progressive increase of Phr and EI from breath to breath. This effect was more evident in animals ventilated by servo- respirator. The higher was the gain of the pump (volume-to-phrenic signal ratio) before the maneuvre, the bigger was the rate of increase of the tidal phrenic amplitude from breath to breath at all CO2, levels tested. Vagotomy strongly depressed or eliminated this effect. We conclude that with intact vagus nerve the increase of respiratory motoneuronal output was only partialy due to the gradual increase in chemical drive when ventilation was stopped. The character of the response indicates the existence of a long-lasting component of the Breuer-Hering reflex. Splitting the medulla abolished this prolonged response while preserving the inspiratory vagal inhibition indicates that the neuronal pathways crossing the midline of .the medulla are important for the effect.
在16只自主呼吸或麻痹并由膈神经驱动泵进行通气的麻醉兔上，研究了迷走神经输入对膈神经（Phr）和肋间外肌（EI）运动神经元输出的长期影响。通过气管阻塞或关闭伺服呼吸器停止通气7次呼吸，会使每次呼吸时Phr和EI逐渐增加。这种效应在由伺服呼吸器通气的动物中更明显。操作前泵的增益（体积与膈神经信号比）越高，在所有测试的二氧化碳水平下，每次呼吸时潮气量膈神经振幅的增加速率就越大。迷走神经切断术强烈抑制或消除了这种效应。我们得出结论，在迷走神经完整的情况下，呼吸运动神经元输出的增加仅部分归因于通气停止时化学驱动的逐渐增加。反应的特征表明存在布雷尔 - 黑林反射的长期成分。将延髓分开消除了这种延长反应，同时保留了吸气性迷走神经抑制，这表明穿过延髓中线的神经元通路对该效应很重要。
