Ho Ming-Chih, Hsiao Ching-Hsi, Sun Ming-Hui, Hwang Yih-Shiou, Lai Chi-Chun, Wu Wei-Chi, Chen Kuan-Jen
Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan 33305, Taiwan.
College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.
Microorganisms. 2021 Aug 30;9(9):1840. doi: 10.3390/microorganisms9091840.
has been reported in various ocular infections, including keratitis, conjunctivitis, preseptal cellulitis, and endophthalmitis, all of which may lead to vision loss. However, the strain is resistant to a wide variety of antibiotics, including penicillins, third-generation cephalosporins, aminoglycosides, and imipenem. In this study, we retrospectively reviewed the clinical characteristics, antibiotic susceptibility, antimicrobial minimum inhibitory concentrations (MICs), and visual outcomes for endophthalmitis. The data of 9 patients with positive cultures in a tertiary referral center from 2010 to 2019 were reviewed. Cataract surgery ( = 8, 89%) was the most common etiology, followed by intravitreal injection ( = 1, 11%). 's susceptibility to levofloxacin and moxifloxacin was observed in 6 cases (67%). Seven isolates were resistant to sulfamethoxazole-trimethoprim (78%). The MIC for was 256, 256, 256, 8, 12, 12, 12, and 8 μg/mL for amikacin, cefuroxime, ceftazidime, tigecycline, sulfamethoxazole-trimethoprim, levofloxacin, galtifloxacin, and moxifloxacin, respectively. Final visual acuity was 20/200 or better in 5 patients (56%). Fluoroquinolones and tigecycline exhibited low antibiotic MIC. Therefore, the results suggest that fluoroquinolones can be used as first-line antibiotics for endophthalmitis.
已在各种眼部感染中被报道，包括角膜炎、结膜炎、睑前蜂窝织炎和眼内炎，所有这些感染都可能导致视力丧失。然而，该菌株对多种抗生素耐药，包括青霉素、第三代头孢菌素、氨基糖苷类和亚胺培南。在本研究中，我们回顾性分析了眼内炎的临床特征、抗生素敏感性、抗菌药物最低抑菌浓度（MIC）和视力转归。回顾了2010年至2019年在一家三级转诊中心9例培养阳性患者的数据。白内障手术（n = 8，89%）是最常见的病因，其次是玻璃体内注射（n = 1，11%）。6例（67%）观察到该菌株对左氧氟沙星和莫西沙星敏感。7株菌株对磺胺甲恶唑-甲氧苄啶耐药（78%）。该菌株对阿米卡星、头孢呋辛、头孢他啶、替加环素、磺胺甲恶唑-甲氧苄啶、左氧氟沙星、加替沙星和莫西沙星的MIC分别为256、256、256、8、12、12、12和8 μg/mL。5例患者（56%）最终视力为20/200或更好。氟喹诺酮类和替加环素的抗生素MIC较低。因此，结果表明氟喹诺酮类可作为眼内炎的一线抗生素。
