School of Nursing, College of Medicine, National Taiwan University, Taipei 100025, Taiwan.
Division of Hematology, Department of Internal Medicine, National Taiwan University Hospital, Taipei 100225, Taiwan.
Nutrients. 2021 Sep 19;13(9):3268. doi: 10.3390/nu13093268.
Short-term calorie reduction (SCR) requires individuals to reduce their calorie intake to less than 50% of normal requirements and has shown good tolerance and potential benefits in prior studies addressing gynecological cancer patients. More studies are needed to further confirm its safety, feasibility, and effects in patients with different cancers, including hematological malignancies. This pilot cohort study with a matched-pair comparison group was registered at ClinicalTrails.gov [201810112RIND]. Adult patients diagnosed with advanced-stage diffuse large-B cell lymphoma were recruited (SCR group) and matched with one comparison patient (comparison group), each in a manner blinded to their outcomes. The SCR group undertook at least two cycles of 48 h water fast along with their chemotherapy R-CHOP. Descriptive analysis and generalized estimating equations were used to analyze the data. Six participants completed multiple cycles of SCR and were compared to their six counterparts in the comparison group. The results showed that SCR is safe and feasible in terms of a high compliance rate and stable nutritional status. The SCR was associated with benefits in post-chemotherapy hematological parameters (i.e., erythrocyte [ < 0.001] and lymphocyte counts [ < 0.001]). More randomized controlled trials are needed to validate the effects of SCR on different types of cancer populations.
短期热量限制（SCR）要求个体将热量摄入减少到正常需求的 50%以下，先前针对妇科癌症患者的研究表明，SCR 具有良好的耐受性和潜在益处。需要更多的研究来进一步证实 SCR 在包括血液恶性肿瘤在内的不同癌症患者中的安全性、可行性和效果。这项具有匹配对照组的前瞻性队列研究已在 ClinicalTrials.gov 注册[201810112RIND]。招募了诊断为晚期弥漫性大 B 细胞淋巴瘤的成年患者（SCR 组），并以盲法方式与一名对照患者（对照组）进行匹配，不了解其结局。SCR 组至少进行了两个周期的 48 小时水禁食，同时接受 R-CHOP 化疗。采用描述性分析和广义估计方程对数据进行分析。六名参与者完成了多个周期的 SCR，并与对照组的六名参与者进行了比较。结果表明，SCR 在高依从率和稳定的营养状况方面是安全且可行的。SCR 与化疗后血液学参数的改善相关（即红细胞[<0.001]和淋巴细胞计数[<0.001]）。需要更多的随机对照试验来验证 SCR 对不同类型癌症人群的影响。
