Faculty of Pharmacy, Integral University, Kursi road, Lucknow 226026 (U.P.), India.
Hygia Institute Of Pharmaceutical Education And Research, Lucknow, India.
Mini Rev Med Chem. 2022;22(7):1064-1080. doi: 10.2174/1389557521666210927124511.
Tuberculosis (TB) is an acute or chronic infectious disease caused by several species of Mycobacterium, collectively called tubercle bacilli or Mycobacterium tuberculosis complex. Around 10 million people get sick with tuberculosis (TB) each year. TB is the second leading cause of death today after HIV/AIDS. A serious problem in the context of MDR-TB is the extensively drug-resistant TB, which is an important reason for the restricted chemotherapy in TB. Therefore, there is a need to explore new antitubercular (anti-TB) agents. Coumarin is an oxygencontaining heterocyclic compound and can be widely found in many natural products, and many of them display diverse biological activities. The wide spectrum of activities of coumarin molecules has intrigued the scientists to explore the natural coumarins and their synthetic derivatives for their potential as anti-TB drugs.
The objective of this review is to emphasize important coumarin analogs with anti-TB activities and their structure-activity relationships (SAR) for designing better anti-TB agents.
Latest, authentic and published reports on various synthetic and natural coumarin derivatives and their anti-TB activities is being thoroughly studied and analyzed. The structural requirements of coumarins as anti-TB drugs have also been studied.
Collection and compilation of reports on various synthetic and natural coumarin derivatives and their anti-TB activities are being performed.
The study provides the latest report on coumarin derivatives synthesized as anti-TB agent and whether their activity depends on structural changes or not.
结核病（TB）是一种由几种分枝杆菌引起的急性或慢性传染病，统称为结核分枝杆菌或结核分枝杆菌复合群。每年约有 1000 万人患上结核病（TB）。结核病（TB）是继艾滋病病毒/艾滋病之后导致死亡的第二大原因。耐多药结核病（MDR-TB）的一个严重问题是广泛耐药结核病（XDR-TB），这是结核病（TB）化疗受限的重要原因。因此，需要探索新的抗结核（anti-TB）药物。香豆素是一种含氧杂环化合物，可广泛存在于许多天然产物中，其中许多具有多种生物活性。香豆素分子的广泛活性引起了科学家的兴趣，他们探索天然香豆素及其合成衍生物作为潜在的抗结核（TB）药物。
本综述的目的是强调具有抗结核（TB）活性的重要香豆素类似物及其构效关系（SAR），以设计更好的抗结核（TB）药物。
对各种合成和天然香豆素衍生物及其抗结核（TB）活性的最新、真实和已发表的报告进行了彻底的研究和分析。还研究了香豆素作为抗结核（TB）药物的结构要求。
正在对各种合成和天然香豆素衍生物及其抗结核（TB）活性的报告进行收集和汇编。
该研究提供了关于合成作为抗结核（TB）药物的香豆素衍生物的最新报告，以及它们的活性是否取决于结构变化。
