DAL-1 基因 rs9953490 多态性与中国东北地区汉族人群胃癌风险相关。

The rs9953490 polymorphism of DAL-1 gene is associated with gastric cancer risk in the Han population in Northeast China.

机构信息

Scientific Research Centre, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150081, China.

Department of Blood Transfusion, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150081, China.

出版信息

BMC Gastroenterol. 2021 Sep 27;21(1):354. doi: 10.1186/s12876-021-01929-9.

DOI:10.1186/s12876-021-01929-9

PMID:34579655

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8477503/

Abstract

BACKGROUND

DAL-1 gene was reported to inhibit proliferation, migration, invasion, and epithelial to mesenchymal transition (EMT) of gastric cancer (GC) cells in our previous study. The association between the genomic variants in DAL-1 gene with risk of GC is still unclear.

METHODS

In this study, 505 GC cases and 544 healthy controls (HCs) were collected to evaluate the association between six single nucleotide polymorphisms (SNPs) (rs7240736, rs73937194, rs3817466, rs8082898, rs73381527, rs9953490) of DAL-1 gene and GC risk in the Han population in Northeast China.

RESULTS

The TA + AA genotypes of rs9953490 were significantly associated with an increased risk in N3 compared with N0 subgroup (adjusted OR = 4.56, 95% CI = 1.49-13.98, P = 0.008), and also showed evident association with an increased risk in TNM stage III compared with stage I-II (adjusted OR = 2.33, 95% CI = 1.16-4.67, P = 0.017).

CONCLUSION

The rs9953490 of DAL-1 gene may play an important role in the occurrence and development of GC in the Han population in Northeast China.

摘要

背景

在我们之前的研究中，DAL-1 基因被报道能抑制胃癌（GC）细胞的增殖、迁移、侵袭和上皮间质转化（EMT）。然而，DAL-1 基因中基因组变异与 GC 风险之间的关联尚不清楚。

方法

本研究共纳入 505 例 GC 病例和 544 例健康对照（HCs），以评估 DAL-1 基因中 6 个单核苷酸多态性（SNPs）（rs7240736、rs73937194、rs3817466、rs8082898、rs73381527、rs9953490）与中国东北地区汉族人群 GC 风险的相关性。

结果

与 rs9953490 的 TA+AA 基因型相比，N3 亚组的 AA 基因型与风险增加显著相关（调整后的 OR=4.56，95%CI=1.49-13.98，P=0.008），且与 TNM 分期 III 相比分期 I-II 也表现出明显的风险增加（调整后的 OR=2.33，95%CI=1.16-4.67，P=0.017）。