Department of Pediatrics, Texas Children's Hospital/ Baylor College of Medicine, 6621 Fannin St., Houston, TX, 77030, USA.
Department of Pediatrics, Renal Section, Texas Children's Hospital/ Baylor College of Medicine, Houston, USA.
BMC Nephrol. 2021 Sep 27;22(1):323. doi: 10.1186/s12882-021-02520-w.
This is a case report of an asymptomatic SARS-CoV-2 infection associated with new-onset nephrotic syndrome in a pediatric patient. This is the third case of new-onset nephrotic syndrome in children associated with SARS-CoV-2 infection, but is the first case report describing a new-onset nephrotic syndrome presentation in a patient who had asymptomatic COVID-19 infection.
This is a case of a previously healthy 5 year old female who presented with new-onset nephrotic syndrome in the setting of an asymptomatic COVID-19 infection. She presented with progressive edema, and laboratory findings were significant for proteinuria and hypercholesterolemia. She was treated with albumin, diuretics, and corticosteroid therapy, and achieved clinical remission of her nephrotic syndrome within 3 weeks of treatment. Though she was at risk of hypercoagulability due to her COVID-19 infection and nephrotic syndrome, she was not treated with anticoagulation, and did not develop any thrombotic events.
Our case report indicates that SARS-CoV-2 infection could be a trigger for nephrotic syndrome, even in the absence of overt COVID-19 symptoms.
这是一例无症状 SARS-CoV-2 感染相关的儿童新发肾病综合征病例报告。这是第三例与 SARS-CoV-2 感染相关的儿童新发肾病综合征病例，但这是首例描述无症状 COVID-19 感染患者新发肾病综合征表现的病例报告。
这是一例既往健康的 5 岁女性，在无症状 COVID-19 感染的背景下出现新发肾病综合征。她表现为进行性水肿，实验室检查显示蛋白尿和高胆固醇血症显著。她接受了白蛋白、利尿剂和皮质类固醇治疗，在治疗 3 周内实现了肾病综合征的临床缓解。尽管由于 COVID-19 感染和肾病综合征，她存在高凝风险，但她没有接受抗凝治疗，也没有发生任何血栓事件。
我们的病例报告表明，SARS-CoV-2 感染可能是肾病综合征的触发因素，即使没有明显的 COVID-19 症状。
