中国广东慢性咳嗽患者的临床特征：一项多中心描述性研究。

Clinical characteristics of patients with chronic cough in Guangdong, China: a multicenter descriptive study.

机构信息

State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, People's Republic of China.

Chronic Airway Disease Laboratory, Department of Respiratory and Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, People's Republic of China.

出版信息

BMC Pulm Med. 2021 Sep 27;21(1):305. doi: 10.1186/s12890-021-01642-z.

DOI:10.1186/s12890-021-01642-z

PMID:34579688

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8477516/

Abstract

BACKGROUND

The clinical characteristics of patients with chronic cough are reported only in single-center survey in China, being significantly different from that in western countries. Here, we performed a multicenter study to describe the clinical characteristics of chronic cough patients.

METHODS

A cross-sectional observational survey was conducted in thirteen tertiary hospitals of Guangdong, South China. Relevant data were recorded using a standardized questionnaire and analyzed, including demographics, educational attainment, cough features, and concomitant symptoms.

RESULTS

Of 933 patients in this study, the median age was 40.0 (IQR 31.0-52.0) years with a peaked age of 30-39 years. The proportion of females (487, 52.2 %) was comparable to that of males (446, 47.8 %). Up to 81.9 % of the patients were non-smokers. More than two-thirds of the subjects with chronic cough had a low educational level. The median cough duration was 6.0 (IQR 3.0-24.0) months, and 73.0 % of chronic cough patients presented with dry cough. Laryngeal paresthesia was the most common concomitant symptom (704, 75.5 %), followed by rhinitis/sinusitis-related (350, 37.5 %) and respiratory symptoms (322, 34.5 %). Rhinitis/sinusitis-related symptoms more frequently occurred in patients with productive cough than in those with dry cough (49.0 % vs. 33.0 %, P < 0.001). Moreover, female patients displayed an older age and a higher prevalence of nocturnal cough compared to male patients (both P < 0.05).

CONCLUSIONS

Our results show an equal gender, young profile and laryngeal paresthesia in patients with chronic cough, and different clinical features between females and males.

摘要

背景

中国的慢性咳嗽患者的临床特征仅在单中心调查中报道，与西方国家明显不同。在这里，我们进行了一项多中心研究，以描述慢性咳嗽患者的临床特征。

方法

对华南地区 13 家三级医院进行横断面观察性调查。使用标准化问卷记录相关数据并进行分析，包括人口统计学、教育程度、咳嗽特征和伴随症状。

结果

在这项研究的 933 名患者中，中位年龄为 40.0（IQR 31.0-52.0）岁，峰值年龄为 30-39 岁。女性（487 例，52.2%）与男性（446 例，47.8%）的比例相当。超过 81.9%的患者为不吸烟者。超过三分之二的慢性咳嗽患者教育程度较低。咳嗽中位数为 6.0（IQR 3.0-24.0）个月，73.0%的慢性咳嗽患者表现为干咳。喉感觉异常是最常见的伴随症状（704 例，75.5%），其次是鼻炎/鼻窦炎相关症状（350 例，37.5%）和呼吸道症状（322 例，34.5%）。有痰咳嗽患者的鼻炎/鼻窦炎相关症状比干咳患者更常见（49.0%比 33.0%，P<0.001）。此外，与男性患者相比，女性患者年龄更大，夜间咳嗽更为常见（均 P<0.05）。