Lai Kefang, Li Vicky W, Chen Lin, Xia Kai, Martin Ashley, Way Nate A, Ding Helen, Fonseca Eileen
National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Oracle Life Sciences, Seattle, WA, USA.
BMC Pulm Med. 2025 May 13;25(1):234. doi: 10.1186/s12890-025-03661-6.
Chronic cough is associated with reduced mental and physical health and increased health care resource use. The lack of nationwide data on chronic cough hinders our understanding of the prevalence, demographics, and impacts of chronic cough in China. The aim of this study was to estimate the lifetime and annual prevalence of chronic cough in mainland China and to describe the sociodemographic and health-related characteristics of adults with chronic cough.
This was a cross-sectional study using self-reported information from a nationally representative sample of 20,051 adults. Respondents with chronic cough (daily cough for ≥ 8 weeks) during the prior 12 months were matched to respondents without chronic cough.
We estimated a lifetime prevalence of 7.0% and an annual prevalence of 4.1% for chronic cough among adult residents of mainland China. Affected individuals had a mean age of 43.5 years, and there were no significant differences in prevalence between men and women. Compared to matched controls, the chronic cough group had more comorbidities and included a higher proportion of individuals who had been diagnosed with respiratory and sleep-related conditions. Chronic cough was also associated with significantly worse depression and anxiety symptom severity and health-related quality of life, as well as increased impairment of work and other daily activities and higher rates of all-cause health care resource use.
Chinese adults with chronic cough show a middle age, equal gender distribution. Chronic cough affects an estimated 46.4 million adults in mainland China during their lifetime and is associated with significant individual and health care system burden.
Chronic cough affects approximately 4.1% (27.2 million) of adults per year in mainland China and is associated with worse health and health-related quality of life, impairment of work productivity and other daily activities, and increased all-cause health care resource use.
慢性咳嗽与身心健康下降以及医疗资源使用增加有关。缺乏全国范围内关于慢性咳嗽的数据阻碍了我们对中国慢性咳嗽的患病率、人口统计学特征及其影响的了解。本研究的目的是估计中国大陆慢性咳嗽的终生患病率和年患病率，并描述慢性咳嗽成人的社会人口学特征和与健康相关的特征。
这是一项横断面研究，使用来自全国代表性的20,051名成年人样本的自我报告信息。将过去12个月内有慢性咳嗽（每日咳嗽≥8周）的受访者与无慢性咳嗽的受访者进行匹配。
我们估计中国大陆成年居民慢性咳嗽的终生患病率为7.0%，年患病率为4.1%。受影响个体的平均年龄为43.5岁，男女患病率无显著差异。与匹配的对照组相比，慢性咳嗽组有更多的合并症，且被诊断患有呼吸和睡眠相关疾病的个体比例更高。慢性咳嗽还与抑郁和焦虑症状严重程度以及与健康相关的生活质量显著更差有关，同时工作和其他日常活动的损害增加以及全因医疗资源使用率更高。
患有慢性咳嗽的中国成年人呈现中年、性别分布均等的特点。慢性咳嗽估计在中国大陆影响4640万成年人的一生，并与重大的个人和医疗系统负担相关。
在中国大陆，慢性咳嗽每年影响约4.1%（2720万）的成年人，并与更差的健康状况、与健康相关的生活质量、工作生产力和其他日常活动的损害以及全因医疗资源使用增加有关。
