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The landscape of mA regulators in small cell lung cancer: molecular characteristics, immuno-oncology features, and clinical relevance.

作者信息

Zhang Chaoqi, Zhang Zhihui, Zhang Zhen, Luo Yuejun, Wu Peng, Zhang Guochao, Xue Liyan, Zeng Qingpeng, Wang Lide, Yang Zhaoyang, Zeng Hua, Zheng Bo, Tan Fengwei, Xue Qi, Gao Shugeng, Sun Nan, He Jie

机构信息

Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.

Biotherapy Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China.

出版信息

Mol Cancer. 2021 Sep 27;20(1):122. doi: 10.1186/s12943-021-01408-5.

DOI:10.1186/s12943-021-01408-5
PMID:34579719
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8474928/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec25/8474928/61c5f521ca52/12943_2021_1408_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec25/8474928/59f4f715997d/12943_2021_1408_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec25/8474928/61c5f521ca52/12943_2021_1408_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec25/8474928/59f4f715997d/12943_2021_1408_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec25/8474928/61c5f521ca52/12943_2021_1408_Fig2_HTML.jpg

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本文引用的文献

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Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries.《全球癌症统计数据 2020:全球 185 个国家和地区 36 种癌症的发病率和死亡率估计》。
CA Cancer J Clin. 2021 May;71(3):209-249. doi: 10.3322/caac.21660. Epub 2021 Feb 4.
2
The role of mA, mC and Ψ RNA modifications in cancer: Novel therapeutic opportunities.mA、mC 和 Ψ RNA 修饰在癌症中的作用:新的治疗机会。
Mol Cancer. 2021 Jan 18;20(1):18. doi: 10.1186/s12943-020-01263-w.
3
Small-cell lung cancer.小细胞肺癌。
对与一碳代谢相关基因及其与肺腺癌预后、肿瘤微环境、化疗耐药性和免疫治疗的关联进行综合分析。
Front Mol Biosci. 2022 Nov 11;9:1034208. doi: 10.3389/fmolb.2022.1034208. eCollection 2022.
4
Comprehensive analysis of N6-methyladenosine-related lncRNAs reveals distinct hepatocellular carcinoma subtypes with immunotherapeutic implications.对N6-甲基腺嘌呤相关长链非编码RNA的综合分析揭示了具有免疫治疗意义的不同肝细胞癌亚型。
Am J Transl Res. 2022 Sep 15;14(9):6504-6520. eCollection 2022.
Nat Rev Dis Primers. 2021 Jan 14;7(1):3. doi: 10.1038/s41572-020-00235-0.
4
Epigenetic landscape of small cell lung cancer: small image of a giant recalcitrant disease.小细胞肺癌的表观遗传学景观:巨大难治性疾病的小缩影。
Semin Cancer Biol. 2022 Aug;83:57-76. doi: 10.1016/j.semcancer.2020.11.006. Epub 2020 Nov 18.
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mA Modification in Coding and Non-coding RNAs: Roles and Therapeutic Implications in Cancer.mA 修饰在编码和非编码 RNA 中的作用及其在癌症中的治疗意义。
Cancer Cell. 2020 Mar 16;37(3):270-288. doi: 10.1016/j.ccell.2020.02.004.
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Immunotherapeutic approaches for small-cell lung cancer.小细胞肺癌的免疫治疗方法。
Nat Rev Clin Oncol. 2020 May;17(5):300-312. doi: 10.1038/s41571-019-0316-z. Epub 2020 Feb 13.
7
Molecular characterization and clinical relevance of mA regulators across 33 cancer types.跨越 33 种癌症类型的 mA 调节剂的分子特征和临床相关性。
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Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.利用 CRISPR-Cas9 筛选技术对癌症治疗靶点进行优先级排序。
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