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利用生物信息学分析鉴定帕金森病潜在核心基因

Identification of Potential Core Genes in Parkinson's Disease Using Bioinformatics Analysis.

作者信息

Quan Wei, Li Jia, Jin Xiya, Liu Li, Zhang Qinghui, Qin Yidan, Pei Xiaochen, Chen Jiajun

机构信息

Department of Neurology, China-Japan Union Hospital of Jilin University, No. 126, Xian Tai Road, Changchun, Jilin 130000, China.

出版信息

Parkinsons Dis. 2021 Sep 17;2021:1690341. doi: 10.1155/2021/1690341. eCollection 2021.

DOI:10.1155/2021/1690341
PMID:34580608
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8464436/
Abstract

PURPOSE

This study aimed to explore new core genes related to the occurrence of Parkinson's disease (PD) and core genes that can lead to the progression of PD.

METHODS

The expression profile data of GSE42966, which contained six substantia nigra tissues isolated from normal individuals and nine substantia nigra tissues isolated from patients with PD, were obtained from Gene Expression Omnibus. Differentially expressed genes (DEGs) were identified, followed by functional enrichment analysis and protein-protein interaction (PPI) network construction. We then identified 10 hub genes and analyzed their expression in different Braak stages.

RESULTS

A total of 773 DEGs were identified that were significantly enriched in metabolic pathways. Ten hub genes were identified through the PPI network, namely, , , , , , , , , , and . The expression of was different in patients with PD with Braak stages 3 and 4.

CONCLUSION

These 10 hub genes and the metabolic pathways they are enriched in may be involved in the pathogenesis of PD. may have potential value in predicting the progression of PD.

摘要

目的

本研究旨在探索与帕金森病（PD）发生相关的新核心基因以及可导致PD进展的核心基因。

方法

从基因表达综合数据库获取GSE42966的表达谱数据，其中包含从正常个体分离的6个黑质组织和从PD患者分离的9个黑质组织。鉴定差异表达基因（DEG），随后进行功能富集分析和蛋白质-蛋白质相互作用（PPI）网络构建。然后我们鉴定了10个枢纽基因并分析了它们在不同Braak分期中的表达。

结果

共鉴定出773个DEG，这些基因在代谢途径中显著富集。通过PPI网络鉴定出10个枢纽基因，即 ， ， ， ， ， ， ， ， ，和 。 在Braak分期为3期和4期的PD患者中表达不同。

结论

这10个枢纽基因及其富集的代谢途径可能参与PD的发病机制。 在预测PD进展方面可能具有潜在价值。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b64/8464436/ac85443cf3e9/PD2021-1690341.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b64/8464436/29088e90fb3b/PD2021-1690341.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b64/8464436/4133445c4f19/PD2021-1690341.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b64/8464436/9626490df6d9/PD2021-1690341.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b64/8464436/101e877a3df0/PD2021-1690341.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b64/8464436/e6b8005734b4/PD2021-1690341.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b64/8464436/32b7405155ae/PD2021-1690341.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b64/8464436/ac85443cf3e9/PD2021-1690341.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b64/8464436/29088e90fb3b/PD2021-1690341.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b64/8464436/4133445c4f19/PD2021-1690341.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b64/8464436/9626490df6d9/PD2021-1690341.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b64/8464436/101e877a3df0/PD2021-1690341.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b64/8464436/e6b8005734b4/PD2021-1690341.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b64/8464436/32b7405155ae/PD2021-1690341.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b64/8464436/ac85443cf3e9/PD2021-1690341.007.jpg

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