Ujita Mari, Abiko Kaoru, Kuwahara Ryo, Emoto Ikuko, Amano Yasuaki, Konishi Ikuo
Department of Obstetrics and Gynecology, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.
Department of Radiology, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.
J Obstet Gynaecol Res. 2021 Dec;47(12):4490-4495. doi: 10.1111/jog.15035. Epub 2021 Sep 27.
Mesonephric-like adenocarcinoma (MLA) is a rare tumor that occurs in the uterine endometrium and ovary. It morphologically and immunohistochemically resembles cervical mesonephric adenocarcinoma (MA). Here, we present a case of MLA of the ovary along with a literature review. An asymptomatic 84-year-old woman presented with a pelvic mass, detected by computerized tomography. Magnetic resonance imaging demonstrated a polycystic mass with a solid component in the left adnexal region. The solid component showed low signal intensity on T2-weighted imaging and high signal intensity on diffusion-weighted imaging. We strongly suspected an ovarian malignant tumor; therefore, surgical resection of the uterus and adnexa was performed. Macroscopically, the tumor was predominantly solid with yellowish-tan cut surface. Microscopically, it showed a tubular pattern with intraluminal colloid-like material resembling MA. The tumor cells were negative for estrogen receptor, calretinin, and CD10 and positive for PAX8 and TTF-1. These findings are consistent with those of MLA.
中肾样腺癌（MLA）是一种罕见的肿瘤，发生于子宫内膜和卵巢。其在形态学和免疫组织化学上类似于宫颈中肾腺癌（MA）。在此，我们报告一例卵巢MLA病例并进行文献复习。一名84岁无症状女性因计算机断层扫描发现盆腔肿块。磁共振成像显示左附件区有一个伴有实性成分的多囊性肿块。实性成分在T2加权成像上呈低信号强度，在扩散加权成像上呈高信号强度。我们高度怀疑为卵巢恶性肿瘤；因此，进行了子宫和附件的手术切除。大体上，肿瘤主要为实性，切面呈黄棕色。显微镜下，其显示出管状结构，管腔内有类似MA的胶体样物质。肿瘤细胞雌激素受体、钙视网膜蛋白和CD10均为阴性，PAX8和TTF-1为阳性。这些发现与MLA相符。
