Department of Pathology, Faculty of Medicine, Usak University, Usak, Turkey.
Int J Clin Pract. 2021 Dec;75(12):e14922. doi: 10.1111/ijcp.14922. Epub 2021 Oct 6.
The present study aimed to investigate the importance and prognostic value of tumour budding (TB) in Gastric Carcinoma (GC).
Pathologic grading of tumours was performed according to the criteria specified by the American Joint Committee on Cancer (AJCC). Histopathologic types, histopathologic grading and all histopathologic characteristics were determined using the Lauren and World Health Organization (WHO) classifications. Forty-three surgically treated GC cases were examined in terms of TB according to the International Tumor Budding Consensus Conference (ITBCC) and budding grading [budding degree (Bd)] was performed. They were recorded as Bd1 (1-4 buddings), Bd2 (5-9 buddings) or Bd3 (10 buddings or more). Bd score, clinicopathologic parameters and prognostic factors were analysed.
There were 13 (30.2%) Bd1, 11 (25.6%) Bd2 and 19 (44.2%) Bd3 cases. A statistically significant relationship was found between Bd scores and pT, N, and histologic grade (P < .01, P < .05). In the Bd1 group, stage pT2 was statistically significantly more frequent than pT3 (P = .001). In the poorly differentiated group, Bd3 was statistically significantly higher than Bd1, but Bd1 was statistically significantly higher than Bd2 in the well-differentiated group (P = .001). In the N0 group, Bd1 was significantly higher than Bd2 and Bd3, whereas Bd2 was higher than Bd1 and Bd3 in the N2 group. Bd3 was higher than Bd1 and Bd2 in the N3 group (P = .001).
In the present study, Bd was statistically significantly related to characteristics such as pathologic stage, lymph node involvement, and grade. The data obtained here suggest that Bd can be applied to GC and it might contribute to the standardisation of diagnosis and prognostic factors.
本研究旨在探讨肿瘤芽（TB）在胃癌（GC）中的重要性和预后价值。
根据美国癌症联合委员会（AJCC）规定的标准对肿瘤进行病理分级。采用 Lauren 和世界卫生组织（WHO）分类法确定组织病理学类型、组织病理学分级和所有组织病理学特征。根据国际肿瘤芽共识会议（ITBCC）和芽分级（Bd）对 43 例手术治疗的 GC 病例进行 TB 检查，并记录为 Bd1（1-4 个芽）、Bd2（5-9 个芽）或 Bd3（10 个或更多芽）。分析 Bd 评分、临床病理参数和预后因素。
Bd1 病例 13 例（30.2%），Bd2 病例 11 例（25.6%），Bd3 病例 19 例（44.2%）。Bd 评分与 pT、N 和组织学分级之间存在统计学显著关系（P<.01，P<.05）。在 Bd1 组中，pT2 期的比例明显高于 pT3 期（P=.001）。在低分化组中，Bd3 明显高于 Bd1，但在高分化组中，Bd1 明显高于 Bd2（P=.001）。在 N0 组中，Bd1 明显高于 Bd2 和 Bd3，而在 N2 组中，Bd2 高于 Bd1 和 Bd3。在 N3 组中，Bd3 高于 Bd1 和 Bd2（P=.001）。
在本研究中，Bd 与病理分期、淋巴结受累和分级等特征有统计学显著关系。本研究获得的数据表明，Bd 可应用于 GC，并可能有助于诊断和预后因素的标准化。
