染色体与妇科医生。

Chromosomes and the gynecologist.

作者信息

van Niekerk W A

出版信息

Am J Obstet Gynecol. 1978 Apr 15;130(8):862-75. doi: 10.1016/0002-9378(78)90263-6.

Abstract

Recent advances in cytogenetic techniques made a valuable contribution toward the modern practice of obstetrics and gynecology. The state of the art regarding the application of these techniques is reviewed in the following areas: the clinical features related to the various sex and autosomal chromosomal anomalies, the cytogenetics of gynecologic malignancies, the chromosomal analysis of spontaneous abortion and of parents with habitual abortions. Chromosome studies in male infertility revealed abnormalities in 11.5 per cent of 69 patients with azoospermia and 9.1 per cent of 165 patients with oligospermia. Among 77 patients with primary amenorrhea, 27.3 per cent revealed chromosomal abnormalities compared to 3.8 per cent in 103 patients with secondary amenorrhea. The term "ovotesticular dysgenesis" is used for the first time in the literature to describe a specific histologic type of streak gonad which contains ovarian stroma and dysgenetic testicular tubules.

摘要

细胞遗传学技术的最新进展为现代妇产科实践做出了宝贵贡献。以下领域对这些技术的应用现状进行了综述：与各种性染色体和常染色体异常相关的临床特征、妇科恶性肿瘤的细胞遗传学、自然流产以及习惯性流产夫妇的染色体分析。男性不育症的染色体研究显示，69例无精子症患者中有11.5%存在异常，165例少精子症患者中有9.1%存在异常。在77例原发性闭经患者中，27.3%显示染色体异常，而103例继发性闭经患者中这一比例为3.8%。文献中首次使用“卵睾发育不全”一词来描述一种特定组织学类型的条索状性腺，其包含卵巢基质和发育不全的睾丸小管。