从 中分离得到的化学成分及其神经保护活性。
Chemical constituents from and their neuroprotective activities.
机构信息
Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning Province, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China.
General Hospital of Northern Theater Command, Shenyang 110016, China.
出版信息
J Asian Nat Prod Res. 2022 Aug;24(8):703-712. doi: 10.1080/10286020.2021.1978987. Epub 2021 Sep 29.
Ten compounds (-) including four new compounds (-) and six known compounds (-) were isolated from . Their structures were elucidated on the basis of spectroscopic data, gauge-including atomic orbital (GIAO) calculation of NMR data, DP4+ probability analysis and comparison of their experimental and calculated electronic circular dichroism (ECD) spectral data. All the isolated compounds were tested for their neuroprotective activities against HO-induced damage in SH-SY5Y cells. Among them, compounds , and displayed moderate neuroprotective effects.
从 中分离得到了 10 种化合物（-），包括 4 种新化合物（-）和 6 种已知化合物（-）。基于光谱数据、NMR 数据的 GIAO 计算、DP4+概率分析以及实验和计算电子圆二色性（ECD）光谱数据的比较，确定了它们的结构。所有分离得到的化合物均进行了神经保护活性测试，以评估其对 HO 诱导的 SH-SY5Y 细胞损伤的保护作用。其中，化合物 、 和 显示出中等的神经保护作用。
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