Madras Diabetes Research Foundation and Dr. Mohan's Diabetes Specialities Centre, Chennai, Tamil Nadu; Ph.D. Scholar, University of Madras, Chennai, Tamil Nadu.
Department of Neurology, School of Medicine, University of New Mexico, USA.
J Assoc Physicians India. 2021 Sep;69(9):11-12.
Although metabolic surgery has been shown to offer beneficial primary outcome results in obese individuals / obese Type 2 diabetes mellitus (T2DM) patients, there is paucity of information on the underlying mechanisms. In the recent years, estimations of non-invasive molecular parameters viz., telomere length and mtDNA copy number (mtDNAcn) assume significance as robust biomarkers. However, there is lack of evidence about this especially, in the Indian context. To assess the changes in the telomere length and mtDNAcn levels after metabolic surgery in obese Asian Indians with dysglycemia along with routine measurements of anthropometry, glycemic/lipidimic parameters and inflammatory markers.
This study is a prospective one-year follow-up study of 16 obese individuals with dysglycemia who underwent metabolic surgery at a tertiary diabetes centre in South India. Telomere length, mtDNAcn, serum adiponectin, glycated haemoglobin and high- sensitivity C-reactive protein (hs-CRP) levels were analysed before surgery and at 6 and 12 months after surgery.
There was a significant reduction in weight (p<0.001), BMI (p<0.001), waist circumference (p<0.001), fasting and postprandial glucose (p<0.05), HbA1c (p<0.001), triglycerides (p<0.05), hs CRP (p<0.05) and increase in serum adiponectin (p<0.05) at 6 and 12 months post-surgery compared to the preoperative status. There was a significant reduction in mtDNAcn (p<0.001) and a significant increase in telomere length (p<0.001) at 6 and 12 months post metabolic surgery.
We report an increase in telomere length and decrease in circulatory mtDNA copy number levels at 6 and 12 months post metabolic surgery in obese individuals with T2DM in India.
尽管代谢手术已被证明能为肥胖个体/肥胖 2 型糖尿病（T2DM）患者带来有益的主要结果，但关于其潜在机制的信息却很少。近年来，端粒长度和线粒体 DNA 拷贝数（mtDNAcn）等非侵入性分子参数的估算作为强有力的生物标志物具有重要意义。然而，特别是在印度，缺乏这方面的证据。本研究旨在评估代谢手术后肥胖的南亚裔糖尿病患者的端粒长度和 mtDNAcn 水平的变化，同时常规测量人体测量学、血糖/脂质参数和炎症标志物。
这是一项在印度南部的一家三级糖尿病中心进行的前瞻性为期 1 年的随访研究，共纳入 16 名患有糖尿病的肥胖患者。在手术前和手术后 6 个月和 12 个月时，分析了端粒长度、mtDNAcn、血清脂联素、糖化血红蛋白和高敏 C 反应蛋白（hs-CRP）水平。
与术前相比，术后 6 个月和 12 个月时体重（p<0.001）、BMI（p<0.001）、腰围（p<0.001）、空腹和餐后血糖（p<0.05）、HbA1c（p<0.001）、甘油三酯（p<0.05）、hs-CRP（p<0.05）显著降低，血清脂联素水平（p<0.05）升高。术后 6 个月和 12 个月时，mtDNAcn（p<0.001）显著降低，端粒长度（p<0.001）显著增加。
我们报告在印度患有 T2DM 的肥胖个体中，代谢手术后 6 个月和 12 个月时端粒长度增加，循环 mtDNA 拷贝数水平降低。
