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心脏、胸和血管手术后成年人的能量摄入、预后和相关指标之间的关系:一项前瞻性观察研究。

Relationship between energy intake, prognosis and related indicators in adults after cardiac, thoracic, and vascular surgery: A prospective observational study.

机构信息

Department of Clinical Nutrition, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Department of Cardiothoracic Surgery, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

出版信息

Asia Pac J Clin Nutr. 2021 Sep;30(3):365-373. doi: 10.6133/apjcn.202109_30(3).0003.

Abstract

BACKGROUND AND OBJECTIVES

The study aimed to explore the association between energy intake (EI), the proportion of enteral nutrition intake (EN%), and prognostic-related indicators.

METHODS AND STUDY DESIGN

This was a prospective observational study. Patients aged 18-80 years old, who had undergone cardiothoracic surgery, were enrolled between January 2017 and January 2018. The measured REE (mREE) was evaluated by indirect calorimetry (IC). The observational data on EI, EN% and EI/mREE% were collected following admission to ICU, ICU discharge, and prior to discharge.

RESULTS

A total of 160 patients (60.6% male) were studied. The prealbumin and total protein were positively correlated with EN% at the time of ICU discharge; liver function index levels were negatively correlated with EI/mREE% at discharge (p<0.05). Multiple linear regression indicated that ALT levels as well as EI/mREE% were related to the duration of mechanical ventilation; ALT, AST, APACHE II were related to the ICU duration; EN% and EI/mREE% were related to the length of stay (LOS) following ICU discharge. EN% was related to the LOS in the hospital.

CONCLUSIONS

The patients treated cardiothoracic surgery demonstrated associations of EN% with LOS in the hospital. Increased EN% and EI/mREE% were associated with higher serum protein levels and maintain normal liver function.

摘要

背景与目的

本研究旨在探讨能量摄入(EI)、肠内营养摄入比例(EN%)与预后相关指标之间的关系。

方法和研究设计

这是一项前瞻性观察性研究。纳入了 2017 年 1 月至 2018 年 1 月期间接受心胸外科手术的 18-80 岁患者。通过间接热量法(IC)评估静息能量消耗(REE)。入院后、入住 ICU 后和出院前,分别采集 EI、EN%和 EI/mREE%的观察数据。

结果

共纳入 160 例患者(60.6%为男性)。在 ICU 出院时,前白蛋白和总蛋白与 EN%呈正相关;肝功能指标水平与出院时的 EI/mREE%呈负相关(p<0.05)。多元线性回归分析表明,ALT 水平以及 EI/mREE%与机械通气时间有关;ALT、AST、APACHE II 与 ICU 持续时间有关;EN%和 EI/mREE%与 ICU 出院后的住院时间(LOS)有关。EN%与住院 LOS 有关。

结论

心胸外科手术后的患者,EN%与住院 LOS 有关。增加 EN%和 EI/mREE%与较高的血清蛋白水平和维持正常肝功能有关。

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