Zhang Y X, Shi T, Su Q R, Deng J K
Shantou University Medical College,Shantou 515041,China.
Usher Institute, the University of Edinburgh, Edinburgh EH8 9AG, UK.
Zhonghua Yi Xue Za Zhi. 2021 Sep 28;101(36):2873-2877. doi: 10.3760/cma.j.cn112137-20210226-00505.
To analyze the clinical characteristics and factors associated with human respiratory syncytial virus (HRSV) infection in preterm infants within the first 2 years of life. Children with respiratory tract infections admitted to Shenzhen Children's Hospital during the 3-year period from January 2016 to December 2018 who were <2 years old and whose gestational age at birth was <37 weeks were selected, and those who met the diagnostic criteria for RSV infection were categorized as the positive case group, and those who had no detectable influenza virus, parainfluenza virus and adenovirus antigens were categorized as the negative group. The clinical characteristics of the case group were retrospectively analyzed. A multivariable logistic regression model was used to analyze the associated factors. A total of 1, 483 children were included, of whom 149 (10.1%) were HRSV positive (case group) and 447 (30.1%) were in the negative group (control group). In the case group, there were 88 (59.1%) male and 61 (40.1%) female children; 127 children (85.2%) in the mild-to-moderate disease group and 22 children (14.8%) in the severe disease group. The number of cases in the severe disease group was greater than that in the mild-to-moderate disease group [(17 cases, 77.3%) than (59 cases, 46.5%)], with statistical significance (=0.010). A total of 117 cases (78.5%) had onset from February to July. Multivariable analysis showed that males [ (95%) of 0.105 (0.013-0.112)], age at month [0.045 (0.036-0.112)], congenital heart disease [0.388 (0.206-0.940)] and bronchopulmonary dysplasia [0.622 (0.484-0.927)] were positively associated with HRSV infection in preterm infants. The high prevalence of HRSV infection in preterm infants in Shenzhen is from February to July each year, and male children are more common. Young age, congenital heart disease and bronchopulmonary dysplasia are all independent risk factors for HRSV infection in preterm infants.
分析出生后2年内早产儿感染人呼吸道合胞病毒（HRSV）的临床特征及相关因素。选取2016年1月至2018年12月期间在深圳市儿童医院住院的年龄<2岁、出生孕周<37周的呼吸道感染患儿，将符合RSV感染诊断标准的患儿分为阳性病例组，将未检测到流感病毒、副流感病毒及腺病毒抗原的患儿分为阴性组。对病例组的临床特征进行回顾性分析。采用多变量logistic回归模型分析相关因素。共纳入1483例患儿，其中149例（10.1%）HRSV阳性（病例组），447例（30.1%）为阴性组（对照组）。病例组中，男童88例（59.1%），女童61例（40.1%）；轻症至中症疾病组127例（85.2%），重症疾病组22例（14.8%）。重症疾病组病例数多于轻症至中症疾病组[（17例，77.3%）比（59例，46.5%）]，差异有统计学意义（P=0.010）。共117例（78.5%）于2月至7月发病。多变量分析显示，男性[比值比（OR）为0.105（0.013～0.112），95%置信区间（CI）]、月龄[OR为0.045（0.036～0.112）]、先天性心脏病[OR为0.388（0.206～0.940）]和支气管肺发育不良[OR为0.622（0.484～0.927）]与早产儿HRSV感染呈正相关。深圳早产儿HRSV感染高发于每年2月至7月，男性患儿更为常见。低月龄、先天性心脏病和支气管肺发育不良均是早产儿HRSV感染的独立危险因素。
