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脊髓原发性黑素细胞瘤:病例研究与康复前景

Primary Melanocytomas of the Spinal Cord: Case Studies and Rehabilitation Perspectives.

作者信息

Covington Stephen, Severson Matthew, Shaeffer Patrick, McGaffey Derek, Garlanger Kristin

机构信息

Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN.

Department of Graduate Medical Education, Saint Louis University School of Medicine, St. Louis, MO.

出版信息

Arch Rehabil Res Clin Transl. 2021 Aug 5;3(3):100143. doi: 10.1016/j.arrct.2021.100143. eCollection 2021 Sep.

Abstract

Primary melanocytomas of the central nervous system are rare tumors arising from leptomeningeal melanocytes. Only 29 cases have been reported in the literature. Presenting symptoms may include insidious onset of back pain, slowly progressive neurologic deficits such as weakness and sensory changes, and bowel and bladder dysregulation. Advanced imaging including magnetic resonance imaging can be helpful in lesion localization but does not distinguish between primary and metastatic melanoma. In this case series, we present 3 patients with nontraumatic spinal cord injuries secondary to primary central nervous system malignant melanocytomas who were admitted to a single inpatient rehabilitation facility within a 12-month time frame. These cases highlight the importance of the rehabilitation team in the continuum of care for patients undergoing resection of primary melanocytomas of the spinal cord. The rehabilitation team should be involved in the preoperative counseling setting, immediately postoperatively, and in follow-up care to assess for signs of recurrence. A comprehensive multidisciplinary approach including physical and occupational therapists, rehabilitation nurses, rehabilitation neuropsychologists, and physiatrists is important for optimizing the function of these patients.

摘要

中枢神经系统原发性黑素细胞瘤是起源于软脑膜黑素细胞的罕见肿瘤。文献中仅报道了29例。临床表现可能包括隐匿性背痛、缓慢进展的神经功能缺损,如无力和感觉改变,以及肠道和膀胱功能失调。包括磁共振成像在内的先进影像学检查有助于病变定位,但无法区分原发性和转移性黑色素瘤。在本病例系列中,我们介绍了3例因原发性中枢神经系统恶性黑素细胞瘤继发非创伤性脊髓损伤的患者,他们在12个月内被收治于同一家住院康复机构。这些病例凸显了康复团队在脊髓原发性黑素细胞瘤切除患者连续护理中的重要性。康复团队应参与术前咨询、术后即刻以及后续护理,以评估复发迹象。包括物理治疗师、职业治疗师、康复护士、康复神经心理学家和物理医学与康复医师在内的全面多学科方法对于优化这些患者的功能至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf59/8463447/9e2b230853e6/gr1.jpg

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