Tremblay Alain, Taghizadeh Niloofar, MacEachern Paul, Burrowes Paul, Graham Andrew J, Lam Stephen C, Yang Huiming, Koetzler Rommy, Tammemägi Martin C, Taylor Kathryn, Bédard Eric L R
Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Department of Diagnostic Imaging, Foothills Medical Center, Alberta Health Services, Calgary, Alberta, Canada.
JTO Clin Res Rep. 2020 Sep 15;2(2):100097. doi: 10.1016/j.jtocrr.2020.100097. eCollection 2021 Feb.
Smoking cessation activities incorporated into lung cancer screening programs have been broadly recommended, but studies to date have not exhibited increased quit rates associated with cessation programs in this setting. We aimed to determine the long-term effectiveness of smoking cessation counseling in smokers presenting for lung cancer screening.
This was a randomized control trial of an intensive, telephone-based smoking cessation counseling intervention incorporating lung cancer screening results versus usual care (information pamphlet). This analysis reports on the long-term impact (24-mo) of the intervention on abstinence from smoking.
A total of 337 active smokers who participated in the screening study were randomized to active smoking cessation counseling (n = 171) or control arm (n = 174) and completed a 24-month assessment. The 30-day smoking abstinence rates at 24 months postrandomization was 18.3% and 21.4% in the control and intervention arms, respectively-a 3.1% difference (95% confidence interval: -5.4 to 11.6, = 0.48). No statistically significant differences in the 7-day abstinence, the use of pharmacologic cessation aids, nicotine replacement therapies, nor intent to quit in the following 30 days were noted ( > 0.05). The abstinence rates at 24-months were higher overall than at 12-months (19.9% versus 13.3%, < 0.001), and smoking intensity was lower than at baseline for ongoing smokers.
A telephone-based smoking cessation counseling intervention incorporating lung cancer screening results did not result in increased long-term cessation rates versus written information alone in unselected smokers undergoing lung cancer screening. Overall, quit rates were high and continued to improve throughout participation in the screening program. (ClinicalTrials.govNCT02431962).
将戒烟活动纳入肺癌筛查项目已得到广泛推荐，但迄今为止的研究并未显示在此背景下戒烟项目能提高戒烟率。我们旨在确定为进行肺癌筛查的吸烟者提供戒烟咨询的长期效果。
这是一项随机对照试验，比较了结合肺癌筛查结果的强化电话戒烟咨询干预与常规护理（信息手册）。本分析报告了该干预对戒烟的长期影响（24个月）。
共有337名参与筛查研究的当前吸烟者被随机分为积极戒烟咨询组（n = 171）或对照组（n = 174），并完成了为期24个月的评估。随机分组后24个月时，对照组和干预组的30天戒烟率分别为18.3%和21.4%，差异为3.1%（95%置信区间：-5.4至11.6，P = 0.48）。在7天戒烟率、使用药物戒烟辅助工具、尼古丁替代疗法以及接下来30天的戒烟意愿方面，未观察到统计学上的显著差异（P>0.05）。24个月时的戒烟率总体高于12个月时（19.9%对13.3%，P<0.001），对于仍在吸烟的人，吸烟强度低于基线水平。
对于接受肺癌筛查的未选择吸烟者，结合肺癌筛查结果的电话戒烟咨询干预与仅提供书面信息相比，并未提高长期戒烟率。总体而言，戒烟率较高，且在整个筛查项目参与过程中持续改善。（ClinicalTrials.govNCT02431962）
