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Acquired Resistance Mechanism for MET Tyrosine Kinase Inhibitor.MET酪氨酸激酶抑制剂的获得性耐药机制
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Oncogene swap as a novel mechanism of acquired resistance to epidermal growth factor receptor-tyrosine kinase inhibitor in lung cancer.癌基因互换作为肺癌中获得性表皮生长因子受体-酪氨酸激酶抑制剂耐药的一种新机制。
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MET and KRAS gene amplification mediates acquired resistance to MET tyrosine kinase inhibitors.MET 和 KRAS 基因扩增介导对 MET 酪氨酸激酶抑制剂的获得性耐药。
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Hepatocyte growth factor expression in EGFR mutant lung cancer with intrinsic and acquired resistance to tyrosine kinase inhibitors in a Japanese cohort.在日本队列中，表皮生长因子受体突变型肺癌对酪氨酸激酶抑制剂的内在和获得性耐药中肝细胞生长因子的表达。
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The combination of multiple receptor tyrosine kinase inhibitor and mammalian target of rapamycin inhibitor overcomes erlotinib resistance in lung cancer cell lines through c-Met inhibition.多种受体酪氨酸激酶抑制剂和哺乳动物雷帕霉素靶蛋白抑制剂的联合应用通过抑制 c-Met 克服了肺癌细胞系对厄洛替尼的耐药性。
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A novel mesenchymal epithelial transition (MET) inhibitor, CB538, relieves acquired resistance in -mutated -amplified non-small cell lung cancer.一种新型间充质上皮转化（MET）抑制剂CB538可缓解EGFR突变、EGFR扩增的非小细胞肺癌中的获得性耐药。
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Dramatic response to crizotinib through MET phosphorylation inhibition in rare TFG-MET fusion advanced squamous cell lung cancer.在罕见的TFG-MET融合晚期肺鳞状细胞癌中，通过抑制MET磷酸化对克唑替尼产生显著反应。
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Phase I Study Evaluating Glesatinib (MGCD265), An Inhibitor of MET and AXL, in Patients with Non-small Cell Lung Cancer and Other Advanced Solid Tumors.评估 MET 和 AXL 抑制剂 Glesatinib（MGCD265）在非小细胞肺癌和其他晚期实体瘤患者中的 I 期研究。
Target Oncol. 2023 Jan;18(1):105-118. doi: 10.1007/s11523-022-00931-9. Epub 2022 Dec 2.
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Case Report: Sequential Combination Targeted Therapy With Type I and II MET Inhibitors in a Metastatic -Mutated, -Amplified NSCLC Patient With Acquired Y1230H Mutation.病例报告：一名转移性、MET突变且扩增的非小细胞肺癌（NSCLC）患者发生获得性Y1230H突变后，序贯联合使用I型和II型MET抑制剂进行靶向治疗
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Differential Pattern of Resistance and Sensitivity to Different Classes of MET Inhibitors for -Amplified Tumors With -D1228X or -Y1230X Mutations.携带G1228X或Y1230X突变的MET扩增肿瘤对不同类别MET抑制剂的耐药和敏感差异模式。
JTO Clin Res Rep. 2021 Mar 16;2(3):100133. doi: 10.1016/j.jtocrr.2020.100133. eCollection 2021 Mar.

本文引用的文献

1
Acquired Resistance to Osimertinib Plus Savolitinib Is Mediated by -D1228 and -Y1230 Mutations in -Mutated -Amplified Lung Cancer.在EGFR突变且扩增的肺癌中，奥希替尼联合赛沃替尼的获得性耐药由EGFR的D1228和Y1230突变介导。
JTO Clin Res Rep. 2020 Nov 1;1(4):100071. doi: 10.1016/j.jtocrr.2020.100071. Epub 2020 Jun 20.
2
Molecular Mechanisms of Acquired Resistance to MET Tyrosine Kinase Inhibitors in Patients with MET Exon 14-Mutant NSCLC.患者 MET 外显子 14 突变型非小细胞肺癌中获得性对 MET 酪氨酸激酶抑制剂耐药的分子机制。
Clin Cancer Res. 2020 Jun 1;26(11):2615-2625. doi: 10.1158/1078-0432.CCR-19-3608. Epub 2020 Feb 7.
3
Sensitivity and Resistance of MET Exon 14 Mutations in Lung Cancer to Eight MET Tyrosine Kinase Inhibitors In Vitro.肺癌中 MET 外显子 14 突变对 8 种 MET 酪氨酸激酶抑制剂的敏感性和耐药性的体外研究。
J Thorac Oncol. 2019 Oct;14(10):1753-1765. doi: 10.1016/j.jtho.2019.06.023. Epub 2019 Jul 3.
4
Osimertinib and Cabozantinib Combinatorial Therapy in an EGFR-Mutant Lung Adenocarcinoma Patient with Multiple MET Secondary-Site Mutations after Resistance to Crizotinib.奥希替尼与卡博替尼联合治疗一名对克唑替尼耐药后出现多个MET二次位点突变的EGFR突变型肺腺癌患者
J Thorac Oncol. 2018 Apr;13(4):e49-e53. doi: 10.1016/j.jtho.2017.10.028. Epub 2017 Nov 8.
5
Glesatinib Exhibits Antitumor Activity in Lung Cancer Models and Patients Harboring Exon 14 Mutations and Overcomes Mutation-mediated Resistance to Type I MET Inhibitors in Nonclinical Models.格来塞替尼在携带外显子 14 突变的肺癌模型和患者中显示出抗肿瘤活性，并克服了非临床模型中 I 型 MET 抑制剂突变介导的耐药性。
Clin Cancer Res. 2017 Nov 1;23(21):6661-6672. doi: 10.1158/1078-0432.CCR-17-1192. Epub 2017 Aug 1.

Acquired Resistance Mechanism for MET Tyrosine Kinase Inhibitor.

作者信息

Fujino Toshio, Mitsudomi Tetsuya

机构信息

Division of Thoracic Surgery, Department of Surgery, Kindai University Faculty of Medicine, Osaka-Sayama, Japan.

出版信息

JTO Clin Res Rep. 2021 Mar 16;2(3):100134. doi: 10.1016/j.jtocrr.2020.100134. eCollection 2021 Mar.

DOI:10.1016/j.jtocrr.2020.100134
PMID:34589997
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8474386/
Abstract
摘要