Zwolińska Weronika, Dmitrzak-Węglarz Monika, Słopień Agnieszka
Department of Child and Adolescent Psychiatry, Poznan University of Medical Sciences, Szpitalna St. 27/33, 60-572, Poznan, Poland.
Department of Psychiatric Genetics, Medical Biology Center, Poznan University of Medical Sciences, Rokietnicka St. 8, 60-806, Poznan, Poland.
Child Psychiatry Hum Dev. 2023 Feb;54(1):266-281. doi: 10.1007/s10578-021-01246-y. Epub 2021 Sep 29.
Despite the significant prevalence of Major Depressive Disorder in the pediatric population, the pathophysiology of this condition remains unclear, and the treatment outcomes poor. Investigating tools that might aid in diagnosing and treating early-onset depression seems essential in improving the prognosis of the future disease course. Recent studies have focused on searching for biomarkers that constitute biochemical indicators of MDD susceptibility, diagnosis, or treatment outcome. In comparison to increasing evidence of possible biomarkers in adult depression, the studies investigating this subject in the youth population are lacking. This narrative review aims to summarize research on molecular and biochemical biomarkers in child and adolescent depression in order to advocate future directions in the research on this subject. More studies on depression involving the youth population seem vital to comprehend the natural course of the disease and identify features that may underlie commonly observed differences in treatment outcomes between adults and children.
尽管重度抑郁症在儿科人群中相当普遍，但这种疾病的病理生理学仍不清楚，治疗效果也很差。研究可能有助于诊断和治疗早发性抑郁症的工具，对于改善未来疾病进程的预后似乎至关重要。最近的研究集中在寻找构成重度抑郁症易感性、诊断或治疗结果生化指标的生物标志物。与成人抑郁症中越来越多的可能生物标志物证据相比，针对青少年人群进行这一主题研究的还比较缺乏。这篇叙述性综述旨在总结儿童和青少年抑郁症分子和生化生物标志物的研究，以便倡导该主题研究的未来方向。开展更多涉及青少年人群的抑郁症研究，对于理解疾病的自然病程以及识别可能是成人和儿童治疗结果常见差异背后的特征似乎至关重要。
