一种本土质谱平台鉴定出能够调节 HSP90-HOP 蛋白-蛋白相互作用的 HOP 抑制剂。
A native mass spectrometry platform identifies HOP inhibitors that modulate the HSP90-HOP protein-protein interaction.
机构信息
FLAIR Research Fellow, School of Chemistry and Physics, Pietermaritzburg Campus, University of KwaZulu-Natal, Private Bag X01, Scottsville, 3209, South Africa.
EaStCHEM School of Chemistry, University of Edinburgh, Joseph Black Building, David Brewster Road, Edinburgh EH93FJ, UK.
出版信息
Chem Commun (Camb). 2021 Oct 19;57(83):10919-10922. doi: 10.1039/d1cc04257b.
Herein we describe a native mass spectromery protein-peptide model as a competent surrogate for the HOP-HSP90 protein-protein interaction (PPI), application of which led to the qualititive identification of two new peptides capable of PPI disruption. This proof of concept study offers a viable alternative for PPI inhibitor screening.
在此，我们描述了一种天然质谱蛋白质-肽模型，它是 HOP-HSP90 蛋白质-蛋白质相互作用 (PPI) 的有效替代物，该模型的应用导致了两种新的能够破坏 PPI 的肽的定性鉴定。这项概念验证研究为 PPI 抑制剂筛选提供了一种可行的替代方法。
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