Ham Hyeongcheol, Shin Seohyun, Ko Gi Hoon, Han Sang Hoon, Han Gi Uk, Maeng Chanyoung, Kim Tae Hyeon, Noh Hee Chan, Lee Kyungsup, Kim Hanjoong, Yang Heejin, Lee Phil Ho
Department of Chemistry, Kangwon National University, Chuncheon 24341, Republic of Korea.
J Org Chem. 2021 Nov 5;86(21):15153-15163. doi: 10.1021/acs.joc.1c01804. Epub 2021 Sep 30.
A direct B(4)-H monoacyloxylation via a Pd-catalyzed regioselective B(4)-H activation of -carborane acids with phenyliodonium dicarboxylates was developed, and a series of B(4)-H monoacyloxylated -carboranes decorated with active groups were synthesized with moderate to good yields as well as excellent selectivity. In addition, a direct B(4,5)-H diacetoxylation from -carborane acids with phenyliodonium diacetate was demonstrated.
通过钯催化的对碳硼烷酸的区域选择性B(4)-H活化与二羧酸苯基碘鎓盐实现了直接的B(4)-H单酰氧基化反应，并以中等到良好的产率以及优异的选择性合成了一系列带有活性基团的B(4)-H单酰氧基化碳硼烷。此外，还证明了碳硼烷酸与二乙酸苯基碘鎓盐之间的直接B(4,5)-H二乙酰氧基化反应。
