Medical School, University of Glasgow, Glasgow, Scotland, UK.
Department of Otorhinolaryngology - Head and Neck Surgery, Queen Elizabeth University Hospital, Glasgow, Scotland, UK.
J Laryngol Otol. 2022 Oct;136(10):934-938. doi: 10.1017/S0022215121002681. Epub 2021 Oct 1.
Vestibular schwannomas can demonstrate great heterogeneity in their behaviour; approximately one-third will grow and two-thirds will not. This study aimed to determine whether there are factors present at diagnosis that can help predict outcomes.
This retrospective cohort study compared data from 735 patients from the past 20 years. Analysis of serial magnetic resonance imaging was carried out to place patients into growing and non-growing cohorts. Factors including size, age, follow-up time and presence of balance symptoms were compared.
The median size of a growing vestibular schwannoma at diagnosis was 13 mm, whereas the non-growing median size was 10.65 mm ( < 0.001). Balance symptoms were present in 60.76 per cent of growing vestibular schwannoma patients but only in 38.75 per cent of patients with non-growing vestibular schwannomas ( < 0.001).
This study highlights initial tumour size and balance symptoms as potential predictors of whether or not a vestibular schwannoma will grow; these results better facilitate our understanding of vestibular schwannoma natural history.
前庭神经鞘瘤的行为具有很大的异质性；约三分之一会生长，三分之二不会。本研究旨在确定诊断时是否存在有助于预测结果的因素。
这项回顾性队列研究比较了过去 20 年的 735 名患者的数据。对连续磁共振成像进行分析，将患者分为生长组和非生长组。比较了大小、年龄、随访时间和平衡症状存在等因素。
生长性前庭神经鞘瘤诊断时的中位数大小为 13mm，而非生长性前庭神经鞘瘤的中位数大小为 10.65mm（<0.001）。生长性前庭神经鞘瘤患者中有 60.76%存在平衡症状，而非生长性前庭神经鞘瘤患者中只有 38.75%存在平衡症状（<0.001）。
本研究强调了初始肿瘤大小和平衡症状作为预测前庭神经鞘瘤是否生长的潜在指标；这些结果更好地帮助我们了解前庭神经鞘瘤的自然史。
