Department of Dermatology, University of Health Sciences, Sultan 2. Abdulhamid Han Training and Research Hospital, Istanbul, Turkey.
Department of Pathology, University of Health Sciences, Sultan 2. Abdulhamid Han Training and Research Hospital, Istanbul, Turkey.
J Wound Care. 2021 Sep 2;30(Sup9a):Vi-Vx. doi: 10.12968/jowc.2021.30.Sup9a.V.
Tamanu is a plant oil derived from the fruit and seeds of the tree. Although scientific data on tamanu oil are limited, it is recommended worldwide for the treatment of abrasions, burns, diabetic wounds and scars. This study aimed to compare the wound healing efficacy of the topical use of tamanu oil with a reference drug in rats.
Uniform wounds were induced on the dorsum of 21 rats, randomly divided into three groups. The control group received normal saline; the tamanu group received tamanu oil; and the centella group was treated with . Wound healing was clinically evaluated using wound healing scoring and wound contraction. A biopsy was taken from the wound sites of each rat on days 7, 14 and 21 for histopathological evaluation.
Wound contraction was significantly lower in the tamanu group compared with the other groups. On day 7, the intensity of macrophage infiltration and mature granulation tissues were significantly higher in the centella and tamanu groups than in the control group. Fibrosis and collagen density were higher in the tamanu group than the other groups on day 7.
In wound healing in rats, tamanu oil accelerated the formation of macrophage-granulation tissues-fibrosis and resulted in less wound contraction.
塔玛努油是一种从该树的果实和种子中提取的植物油。尽管关于塔玛努油的科学数据有限，但它在世界范围内被推荐用于治疗擦伤、烧伤、糖尿病伤口和疤痕。本研究旨在比较塔玛努油与参考药物在治疗大鼠创面愈合方面的疗效。
在 21 只大鼠的背部均匀诱导创面，随机分为三组。对照组给予生理盐水；塔玛努组给予塔玛努油；积雪草组用 治疗。采用创面愈合评分和创面收缩对创面愈合进行临床评价。在第 7、14 和 21 天，从每组大鼠的创面采集活检组织进行组织病理学评价。
与其他组相比，塔玛努组的创面收缩明显较低。第 7 天，积雪草组和塔玛努组的巨噬细胞浸润和成熟肉芽组织的强度明显高于对照组。第 7 天，塔玛努组的纤维化和胶原密度高于其他组。
在大鼠创面愈合中，塔玛努油加速了巨噬细胞-肉芽组织-纤维化的形成，导致创面收缩减少。
