Division of Pulmonary, Critical Care, and Sleep Medicine, Mayo Clinic Health System, Franciscan Healthcare in La Crosse, La Crosse, WI, USA.
Department of Mechanical Engineering, University of Kentucky College of Engineering, Lexington, KY, USA.
Am J Med Sci. 2021 Dec;362(6):537-545. doi: 10.1016/j.amjms.2021.09.004. Epub 2021 Sep 28.
Mechanical ventilation is a potentially life-saving therapy for patients with acute lung injury, but the ventilator itself may cause lung injury. Ventilator-induced lung injury (VILI) is sometimes an unfortunate consequence of mechanical ventilation. It is not clear however how best to minimize VILI through adjustment of various parameters including tidal volume, plateau pressure, driving pressure, and positive end expiratory pressure (PEEP). No single parameter provides a clear indication for onset of lung injury attributable exclusively to the ventilator. There is currently interest in quantifying how static and dynamic parameters contribute to VILI. One concept that has emerged is the consideration of the amount of energy transferred from the ventilator to the respiratory system per unit time, which can be quantified as mechanical power. This review article reports on recent literature in this emerging field and future roles for mechanical power assessments in prospective studies.
机械通气是治疗急性肺损伤患者的一种有潜在救生作用的疗法,但通气机会导致肺损伤。通气机所致肺损伤(VILI)有时是机械通气的不幸后果。然而,通过调整潮气量、平台压、驱动压和呼气末正压(PEEP)等各种参数,如何最佳地将 VILI 最小化尚不清楚。没有单一的参数可以清楚地表明完全由通气机引起的肺损伤。目前,人们对量化静态和动态参数对 VILI 的影响很感兴趣。出现的一个概念是考虑单位时间内从通气机传递到呼吸系统的能量量,这可以作为机械功率进行量化。这篇综述文章报告了这一新兴领域的最新文献以及机械功率评估在未来前瞻性研究中的作用。