Bernfeld P, Homburger F, Adams R A, Soto E, Van Dongen C G
J Natl Cancer Inst. 1986 Jul;77(1):165-71.
Base-line data in over 600 control animals of both sexes of the first-generation hybrid BIO F1D Alexander strain of Syrian golden hamsters are presented. They involve mortality, body weights, spontaneous tumor incidence, and incidence of nonneoplastic lesions. The results confirmed previously published data on smaller numbers of animals of this hamster strain. Spontaneous tumors with an incidence of more than 2% were limited to lymphomas (less than or equal to 6%), adrenocortical carcinomas (less than 8%), adrenal adenomas (9-14% in males; 3.5% in females), islet cell adenomas (less than 6%), and follicular adenomas of the thyroid gland (3.5% in females only). This low incidence of spontaneous tumors and the high survival rate (compared to those of hamsters from other sources), together with the previously established high susceptibility to tumor induction by carcinogen administration, render the F1D Alexander hamster an excellent animal model for lifetime carcinogenesis bioassays.
本文呈现了超过600只第一代杂交BIO F1D叙利亚金仓鼠（两种性别）对照动物的基线数据。这些数据包括死亡率、体重、自发肿瘤发生率和非肿瘤性病变发生率。结果证实了之前发表的关于该仓鼠品系较少数量动物的数据。发生率超过2%的自发肿瘤仅限于淋巴瘤（小于或等于6%）、肾上腺皮质癌（小于8%）、肾上腺腺瘤（雄性为9 - 14%；雌性为3.5%）、胰岛细胞瘤（小于6%）以及甲状腺滤泡腺瘤（仅在雌性中为3.5%）。这种自发肿瘤的低发生率和高存活率（与其他来源的仓鼠相比），再加上先前确定的对致癌物给药诱导肿瘤的高易感性，使得F1D亚历山大仓鼠成为终生致癌生物测定的优秀动物模型。
