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经导管主动脉瓣置换术的电生理影响:发生率、结局和当前管理策略。

Electrophysiologic Implications of Transcatheter Aortic Valve Replacement: Incidence, Outcomes, and Current Management Strategies.

机构信息

Division of Cardiology, Section of Electrophysiology, University of Colorado, 12401 E. 17th Ave., MS B-136, Aurora, CO, 80045, USA.

Denver VA Medical Center, Denver, USA.

出版信息

Curr Cardiol Rep. 2021 Oct 1;23(11):167. doi: 10.1007/s11886-021-01599-9.

DOI:10.1007/s11886-021-01599-9
PMID:34599417
Abstract

PURPOSE OF REVIEW

Transcatheter aortic valve replacement (TAVR) has changed the paradigm for management of severe aortic stenosis. Despite substantial procedural advancements, conduction system abnormalities remain a common complication following TAVR. In this review, we describe (1) incidence and risk factors for the development of conduction disturbances following TAVR, along with their prognostic significance, (2) the incidence and prognostic significance of new-onset arrhythmias following TAVR, (3) approach to management of perioperative and post-procedural conduction disturbances and arrhythmias, and (4) novel areas of research.

RECENT FINDINGS

Conduction disturbances including left bundle branch block (LBBB) and high-grade atrioventricular block (HAVB) remain common issues post-TAVR despite advancements in valve technology and improvements in procedural technique. Despite data showing most conduction abnormalities resolve over time, rates of post-procedural permanent pacemaker implantation remain high. Similarly, rates of new-onset or newly detected arrhythmia, particularly atrial fibrillation, have been widely reported post-implantation of all types of TAVR valves. Recent consensus statements and decision pathway documents have been helpful in standardizing an approach to post-TAVR conduction disturbances. New areas of research show promise both for predicting which patients will develop conduction disturbances post-TAVR and for management of HAVB with novel pacing techniques. On the other hand, management of new-onset or newly detected atrial fibrillation after TAVR remains a significant challenge without standardized treatment strategy.

摘要

目的综述

经导管主动脉瓣置换术(TAVR)改变了严重主动脉瓣狭窄的治疗模式。尽管手术技术取得了重大进展,但传导系统异常仍然是 TAVR 后的常见并发症。在这篇综述中,我们描述了(1)TAVR 后发生传导障碍的发生率和危险因素,以及它们的预后意义,(2)TAVR 后新发心律失常的发生率和预后意义,(3)围手术期和术后传导障碍和心律失常的处理方法,以及(4)新的研究领域。

最近的发现

尽管瓣膜技术的进步和手术技术的改进,传导障碍(包括左束支传导阻滞(LBBB)和高度房室传导阻滞(HAVB))仍然是 TAVR 后常见的问题。尽管数据显示大多数传导异常随时间逐渐缓解,但术后永久性起搏器植入的发生率仍然很高。同样,各种 TAVR 瓣膜植入后新发或新发现的心律失常(特别是心房颤动)的发生率也被广泛报道。最近的共识声明和决策路径文件有助于规范 TAVR 后传导障碍的处理方法。新的研究领域在预测哪些患者会在 TAVR 后发生传导障碍以及使用新型起搏技术治疗 HAVB 方面显示出了希望。另一方面,在没有标准化治疗策略的情况下,TAVR 后新发或新发现的心房颤动的管理仍然是一个重大挑战。

相似文献

1
Electrophysiologic Implications of Transcatheter Aortic Valve Replacement: Incidence, Outcomes, and Current Management Strategies.经导管主动脉瓣置换术的电生理影响:发生率、结局和当前管理策略。
Curr Cardiol Rep. 2021 Oct 1;23(11):167. doi: 10.1007/s11886-021-01599-9.
2
A Disruptive Technology: Determining Need for Permanent Pacing After TAVR.一种颠覆性技术:经 TAVR 后确定是否需要永久性起搏。
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Conduction Abnormalities and Permanent Pacemaker Implantation After Transcatheter Aortic Valve Replacement Using the Repositionable LOTUS Device: The United Kingdom Experience.经导管主动脉瓣置换术使用可重定位 LOTUS 装置后的传导异常和永久性起搏器植入:英国经验。
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Temporal Incidence and Predictors of High-Grade Atrioventricular Block After Transcatheter Aortic Valve Replacement.经导管主动脉瓣置换术后高度房室传导阻滞的时间发生率及预测因素。
J Am Heart Assoc. 2021 May 18;10(10):e020033. doi: 10.1161/JAHA.120.020033. Epub 2021 May 7.
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本文引用的文献

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STS-ACC TVT Registry of Transcatheter Aortic Valve Replacement.经导管主动脉瓣置换术的STS-ACC TVT注册研究
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Feasibility and stability of left bundle branch pacing in patients after prosthetic valve implantation.
人工瓣膜植入术后患者行左束支起搏的可行性和稳定性。
Clin Cardiol. 2020 Oct;43(10):1110-1118. doi: 10.1002/clc.23413. Epub 2020 Jul 1.
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His-Purkinje Conduction System Pacing Following Transcatheter Aortic Valve Replacement: Feasibility and Safety.经导管主动脉瓣置换术后希氏束-浦肯野传导系统起搏:可行性与安全性
JACC Clin Electrophysiol. 2020 Jun;6(6):649-657. doi: 10.1016/j.jacep.2020.02.010. Epub 2020 May 6.
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The Utility of Rapid Atrial Pacing Immediately Post-TAVR to Predict the Need for Pacemaker Implantation.经 TAVR 术后即刻行快速心房起搏在预测起搏器植入需求中的作用。
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Feasibility of His-bundle pacing in patients with conduction disorders following transcatheter aortic valve replacement.经导管主动脉瓣置换术后传导障碍患者希氏束起搏的可行性。
J Cardiovasc Electrophysiol. 2020 Apr;31(4):813-821. doi: 10.1111/jce.14371. Epub 2020 Feb 5.
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Impact of Sapien 3 Balloon-Expandable Versus Evolut R Self-Expandable Transcatheter Aortic Valve Implantation in Patients With Aortic Stenosis: Data From a Nationwide Analysis.Sapien 3 球囊扩张式与 Evolut R 自膨式经导管主动脉瓣置换术治疗主动脉瓣狭窄患者的影响:来自全国性分析的数据。
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8
Development of a Risk Score to Predict New Pacemaker Implantation After Transcatheter Aortic Valve Replacement.经导管主动脉瓣置换术后预测新起搏器植入风险评分的开发。
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9
New-onset left bundle branch block after transcatheter aortic valve replacement is associated with adverse long-term clinical outcomes in intermediate-risk patients: an analysis from the PARTNER II trial.经导管主动脉瓣置换术后新发左束支传导阻滞与中危患者不良长期临床结局相关:来自 PARTNER II 试验的分析。
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