Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
J Neuroimmunol. 2021 Nov 15;360:577718. doi: 10.1016/j.jneuroim.2021.577718. Epub 2021 Sep 10.
Autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy is a recently defined autoimmune meningoencephalomyelitis, associated with GFAP-IgG antibody. A pooled analysis of 324 cases from published literature and a retrospective single-center study were performed, firstly reveals the possibility that patients with myelitic lesions respond better to initial immunotherapy, but are prone to relapse, suggesting a more aggressive and long-term immunosuppressive medication for them. Moreover, our results showed using tacrolimus at maintenance stage exhibited a less tendency to relapse, providing a possibly new choice to future clinical treatments.
自身免疫性神经胶质纤维酸性蛋白（GFAP）星形胶质细胞病是一种新近定义的自身免疫性脑脊髓炎，与 GFAP-IgG 抗体有关。对已发表文献中的 324 例病例进行的汇总分析和回顾性单中心研究首次表明，有脊髓病变的患者对初始免疫治疗的反应更好，但容易复发，这提示他们需要更积极和长期的免疫抑制药物治疗。此外，我们的结果表明，在维持阶段使用他克莫司显示出较低的复发倾向，为未来的临床治疗提供了一种可能的新选择。
