Department of Animal Science, College of Agriculture and Natural Resources, University of Tehran, Alborz, Karaj, Iran.
Department of Animal Science, College of Agriculture and Natural Resources, University of Tehran, Alborz, Karaj, Iran.
Poult Sci. 2021 Nov;100(11):101418. doi: 10.1016/j.psj.2021.101418. Epub 2021 Aug 8.
Japanese quail is an increasingly important bird of economic importance for commercial egg and meat production, particularly in developing countries. There is a need for research aimed at improving efficiency of these birds during stressful challenges, such as oxidative stress. Coenzyme Q10 (CoQ10), a highly functional antioxidant, protects cells against oxidative stress. This study was conducted to determine the effects of CoQ10 on reproductive performance of Japanese quail under cadmium (Cd) challenge. A total of 216 six-wk-old Japanese quail were randomly allocated into 3 groups for an 8 wk experimental trial. The treatments include a negative control (NC): feeding basal diet; a positive control (PC): feeding basal diet and cadmium administration (1 mg/100 g BW, at 10 and 11 wk of age), and (CdQ10): feeding CoQ10 supplemented (900 mg/kg diet) basal diet and Cd administration. At 11 and 13 wk of age, egg production, body weight, mortality, oviduct, and ovarian biometry, were recorded. Histology and histopathology of isthmus and magnum, fertility, hatchability, hatchling quality, and HSP70 mRNA transcript abundance in the utero-vaginal junction (UVJ) were evaluated. Positive control and CdQ10 group had no significant effect on live body weight, stroma weight, follicle size, hatchability, and fertility; however, Cd administration increased (P < 0.01) mortality rate in the PC group compared to the NC and CdQ10 groups. CdQ10 quail produced more eggs and had a higher hatchling quality compared to the PC group (P < 0.01). The thickness and height of isthmus and magnum folds in the CdQ10 group was increased compared to the PC group (P < 0.01) and overall oviduct weight was increased with CoQ10 supplementation (P < 0.01). Compared to PC, the CdQ10 group had a reduction in infiltration of inflammatory cells. Relative abundance of HSP70 mRNA in UVJ was influenced by interactive effect of treatment × time (P < 0.05). In conclusion, dietary supplementation of CoQ10 showed beneficial effects on some reproduction characteristics of female Japanese quail under Cd-induced oxidative stress.
鹌鹑是一种经济重要性日益增加的鸟类，用于商业蛋和肉生产，特别是在发展中国家。需要研究旨在提高这些鸟类在应激挑战下的效率，例如氧化应激。辅酶 Q10（CoQ10）是一种高度功能性的抗氧化剂，可保护细胞免受氧化应激。这项研究旨在确定 CoQ10 在镉（Cd）挑战下对鹌鹑繁殖性能的影响。总共 216 只 6 周龄的鹌鹑被随机分配到 3 个组进行 8 周的实验。处理包括阴性对照（NC）：喂食基础饮食；阳性对照（PC）：喂食基础饮食和镉处理（1mg/100g BW，在 10 和 11 周龄时），和（CdQ10）：喂食补充 CoQ10（900mg/kg 饮食）的基础饮食和 Cd 处理。在 11 和 13 周龄时，记录产蛋量、体重、死亡率、输卵管和卵巢生物测量、组织学和组织病理学、输卵管峡部和子宫部、受精率、孵化率、孵化雏鸡质量和 utero-vaginal 交界处（UVJ）中的 HSP70mRNA 转录丰度。阳性对照和 CdQ10 组对活体体重、基质重量、卵泡大小、孵化率和受精率没有显著影响；然而，与 NC 和 CdQ10 组相比，PC 组的死亡率增加（P<0.01）。与 PC 组相比，CdQ10 组产蛋更多，孵化雏鸡质量更高（P<0.01）。与 PC 组相比，CdQ10 组输卵管峡部和子宫部折叠的厚度和高度增加（P<0.01），并且 CoQ10 补充增加了总输卵管重量（P<0.01）。与 PC 组相比，CdQ10 组炎性细胞浸润减少。在处理×时间的交互作用下（P<0.05），UVJ 中 HSP70mRNA 的相对丰度受到影响。总之，日粮补充 CoQ10 对 Cd 诱导的氧化应激下雌性鹌鹑的一些繁殖特性表现出有益的影响。
