Department of Paediatrics, School of Medical Sciences, Universiti Sains Malaysia; Hospital Universiti Sains Malaysia, Health Campus, Universiti Sains Malaysia, Kelantan, Malaysia.
Singapore Med J. 2023 Sep;64(9):557-562. doi: 10.11622/smedj.2021128.
The study was performed to determine the psychological problems in children with idiopathic nephrotic syndrome (INS) while they were on steroid therapy, as compared to healthy children.
This prospective cohort study was conducted in a paediatric clinic of a tertiary hospital. Parents of the participants in the INS group and control group (comprising children without chronic illness) completed questionnaires using the Child Behavioural Checklist (CBCL). The CBCL measures a range of age-specific emotional and psychological problems, including internalising and externalising domains. Analyses of the CBCL scores between groups were done using Mann-Whitney U test.
A total of 140 children were recruited with an equal number in the INS and control groups. There was a significant difference in the mean total CBCL scores between the INS group and the control group, specifically in the withdrawal, somatic, anxious and aggressiveness subdomains. Similar findings were demonstrated in correlation between total psychological problems and corticosteroid dosage. In the INS group, steroid dose and cushingoid features were found to have a significant positive association with internalising psychological problems.
Children with INS on corticosteroid treatment showed an increase in internalising and externalising scores, as compared to healthy children.
本研究旨在比较特发性肾病综合征（INS）患儿在接受类固醇治疗期间与健康儿童相比存在哪些心理问题。
这是一项在一家三级医院儿科诊所进行的前瞻性队列研究。INS 组和对照组（包括无慢性疾病的儿童）的家长使用儿童行为检查表（CBCL）完成问卷。使用 Mann-Whitney U 检验对两组间 CBCL 评分进行分析。
共招募了 140 名儿童，INS 组和对照组各有 70 名儿童。INS 组与对照组的 CBCL 总分存在显著差异，特别是在退缩、躯体、焦虑和攻击行为等子领域。在总心理问题与皮质类固醇剂量之间的相关性中也得到了类似的发现。在 INS 组中，皮质类固醇剂量和库欣样特征与内在心理问题呈显著正相关。
与健康儿童相比，接受皮质类固醇治疗的 INS 患儿的内在和外在评分均升高。
