Moore Jeremy P, Gallotti Roberto G, Shannon Kevin M, Blais Benjamin A, DeWitt Elizabeth S, Chiu Shuenn-Nan, Spar David S, Fish Frank A, Shah Maully J, Ernst Sabine, Khairy Paul, Kanter Ronald J, Chang Philip M, Pilcher Thomas, Law Ian H, Silver Eric S, Wu Mei-Hwan
Division of Cardiology, Department of Medicine, UCLA Medical Center, Ahmanson/UCLA Adult Congenital Heart Disease Center, Los Angeles, California, USA; UCLA Cardiac Arrhythmia Center, UCLA Health System, David Geffen School of Medicine at UCLA, Los Angeles, California, USA; Division of Cardiology, Department of Pediatrics, UCLA Medical Center, Los Angeles, California, USA.
Division of Cardiology, Department of Medicine, UCLA Medical Center, Ahmanson/UCLA Adult Congenital Heart Disease Center, Los Angeles, California, USA; UCLA Cardiac Arrhythmia Center, UCLA Health System, David Geffen School of Medicine at UCLA, Los Angeles, California, USA; Division of Cardiology, Department of Pediatrics, UCLA Medical Center, Los Angeles, California, USA.
JACC Clin Electrophysiol. 2022 Mar;8(3):322-330. doi: 10.1016/j.jacep.2021.08.004. Epub 2021 Sep 29.
This study sought to describe the electrophysiologic properties and catheter ablation outcomes for atrioventricular reciprocating tacchycardia via twin atrioventricular nodes (T-AVRT).
Although catheter ablation for T-AVRT is an established entity, there are few data on the electrophysiological properties and outcomes of this procedure.
An international, multicenter study was conducted to collect retrospective procedural and outcomes data for catheter ablation of T-AVRT.
Fifty-nine patients with T-AVRT were identified (median age at procedure, 8 years [interquartile range: 4.4-17.0 years]; 49% male). Of these, 55 (93%) were diagnosed with heterotaxy syndrome (right atrial isomerism in 39, left atrial isomerism in 8, and indeterminate in 8). Twenty-three (39%) had undergone Fontan operation (12 extracardiac, 11 lateral tunnel). After the Fontan operation, atrial access was conduit or baffle puncture in 15 (65%), fenestration in 5 (22%), and retrograde in 3 (13%). Acute success was achieved in 43 (91%) of 47 attempts (targeting an anterior node in 23 and posterior node in 24). There was no high-grade AV block or change in QRS duration. Over a median of 3.8 years, there were 3 recurrences. Of 7 patients with failed index procedure or recurrent T-AVRT, 6 (86%) were associated with anatomical hurdles such as prior Fontan or catheter course through an interrupted inferior vena cava-to-azygous vein continuation (P = 0.11).
T-AVRT can be targeted successfully with low risk for recurrence. Complications were rare in this population. Anatomical challenges were common among patients with reduced short and long-term efficacy, representing opportunities for improvement in procedural timing and planning.
本研究旨在描述经双房室结(T-AVRT)的房室折返性心动过速的电生理特性及导管消融结果。
尽管T-AVRT的导管消融已成为既定治疗方法,但关于该手术的电生理特性和结果的数据较少。
开展一项国际多中心研究,收集T-AVRT导管消融的回顾性手术及结果数据。
共纳入59例T-AVRT患者(手术时的中位年龄为8岁[四分位间距:4.4 - 17.0岁];49%为男性)。其中,55例(93%)被诊断为异构综合征(39例为右心房异构,8例为左心房异构,8例不确定)。23例(39%)接受过Fontan手术(12例为心外手术,11例为侧隧道手术)。Fontan手术后,15例(65%)通过管道或挡板穿刺进入心房,5例(22%)通过开窗进入,3例(13%)通过逆行进入。47次尝试中有43次(91%)取得急性成功(23次针对前结,24次针对后结)。未发生高度房室传导阻滞或QRS时限改变。中位随访3.8年期间,有3例复发。在7例初次手术失败或T-AVRT复发的患者中,6例(86%)与解剖学障碍有关,如既往Fontan手术或导管经中断的下腔静脉至奇静脉延续处的走行(P = 0.11)。
T-AVRT可成功靶向治疗,复发风险低。该人群并发症罕见。解剖学挑战在短期和长期疗效不佳的患者中很常见,这为改进手术时机和规划提供了机会。