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可溶性 LAG-3 和 Toll 相互作用蛋白：帕金森病的新型上游神经炎症标志物。

Soluble LAG-3 and Toll-interacting protein: Novel upstream neuro-inflammatory markers in Parkinson's disease.

机构信息

Department of Neurology, Institute of Neurosciences Kolkata, Kolkata, India; Department of Physiology, University of Calcutta, Kolkata, India.

Department of Neurology, Institute of Neurosciences Kolkata, Kolkata, India.

出版信息

Parkinsonism Relat Disord. 2021 Oct;91:121-123. doi: 10.1016/j.parkreldis.2021.09.019. Epub 2021 Sep 25.

DOI:10.1016/j.parkreldis.2021.09.019
PMID:34601340
Abstract

INTRODUCTION

There is some evidence regarding the role of LAG-3, TLR mediated neuroinflammation in PD.

METHODS

sLAG-3, TOLLIP, NLRP3 levels were measured in PD and healthy controls.

RESULTS

These markers were significantly higher in PD and were associated with progression.

CONCLUSION

sLAG3 and TOLLIP are involved in the NLRP3 mediated inflammatory activation in PD.

摘要

介绍

有一些关于 LAG-3、TLR 介导的神经炎症在 PD 中的作用的证据。

方法

在 PD 和健康对照组中测量 sLAG-3、TOLLIP、NLRP3 水平。

结果

这些标志物在 PD 中显著升高，并与进展相关。

结论

sLAG3 和 TOLLIP 参与了 PD 中 NLRP3 介导的炎症激活。

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